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CXXC4 CXXC finger protein 4 [ Homo sapiens (human) ]

Gene ID: 80319, updated on 11-Jun-2021

Summary

Official Symbol
CXXC4provided by HGNC
Official Full Name
CXXC finger protein 4provided by HGNC
Primary source
HGNC:HGNC:24593
See related
Ensembl:ENSG00000168772 MIM:611645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDAX
Summary
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in brain (RPKM 4.6), thyroid (RPKM 1.9) and 20 other tissues See more
Orthologs
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Genomic context

See CXXC4 in Genome Data Viewer
Location:
4q24
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (104468308..104494967, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (105389465..105416051, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377350 Neighboring gene VISTA enhancer hs260 Neighboring gene CXXC4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 3032 Neighboring gene ribosomal protein L6 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CXXC finger protein 4 (CXXC4; IDAX) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149872

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zygotic specification of dorsal/ventral axis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CXXC-type zinc finger protein 4
Names
CXXC finger 4
Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
inhibition of the Dvl and axin complex protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025212.4NP_079488.2  CXXC-type zinc finger protein 4

    See identical proteins and their annotated locations for NP_079488.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AA708035, AC093628, AK125395, CB068467, DA804531
    Consensus CDS
    CCDS3665.2
    UniProtKB/TrEMBL
    J9JIF5
    Related
    ENSP00000378248.2, ENST00000394767.3
    Conserved Domains (1) summary
    pfam02008
    Location:301341
    zf-CXXC; CXXC zinc finger domain

RNA

  1. NR_132741.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon and lacks another alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA708035, AC093628, AK125395, CB068467, CR627201, DA397981

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    104468308..104494967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532284.2XP_011530586.1  CXXC-type zinc finger protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011530586.1

    UniProtKB/TrEMBL
    J9JIF5
    Conserved Domains (1) summary
    pfam02008
    Location:301341
    zf-CXXC; CXXC zinc finger domain
  2. XM_017008652.1XP_016864141.1  CXXC-type zinc finger protein 4 isoform X1

    UniProtKB/TrEMBL
    J9JIF5
    Conserved Domains (1) summary
    pfam02008
    Location:301341
    zf-CXXC; CXXC zinc finger domain
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