U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRRC27 leucine rich repeat containing 27 [ Homo sapiens (human) ]

Gene ID: 80313, updated on 12-Aug-2022

Summary

Official Symbol
LRRC27provided by HGNC
Official Full Name
leucine rich repeat containing 27provided by HGNC
Primary source
HGNC:HGNC:29346
See related
Ensembl:ENSG00000148814 AllianceGenome:HGNC:29346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 8.7), brain (RPKM 1.4) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LRRC27 in Genome Data Viewer
Location:
10q26.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132330063..132381508)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133274838..133327017)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134145697..134195012)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene uncharacterized LOC124902526 Neighboring gene PWWP domain containing 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
leucine-rich repeat-containing protein 27
Names
testicular tissue protein Li 108

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143757.2NP_001137229.1  leucine-rich repeat-containing protein 27 isoform a

    See identical proteins and their annotated locations for NP_001137229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB051461, AK097418, AL512722, AL590105, DA203895
    Consensus CDS
    CCDS31316.1
    UniProtKB/Swiss-Prot
    Q8NA21, Q9C0I9
    UniProtKB/TrEMBL
    A0A140VJN2, B3KUK5
    Related
    ENSP00000357602.4, ENST00000368613.8
    Conserved Domains (4) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12302
    Location:331471
    DUF3629; Protein of unknown function (DUF3629)
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  2. NM_001143758.2NP_001137230.1  leucine-rich repeat-containing protein 27 isoform b

    See identical proteins and their annotated locations for NP_001137230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a distinct splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL590105, BC050097
    Consensus CDS
    CCDS44495.1
    UniProtKB/Swiss-Prot
    Q9C0I9
    Related
    ENSP00000486582.1, ENST00000625755.2
    Conserved Domains (2) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  3. NM_001143759.2NP_001137231.1  leucine-rich repeat-containing protein 27 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate exon and uses a distinct splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK098652, AL590105, BX117491
    Consensus CDS
    CCDS44496.1
    UniProtKB/Swiss-Prot
    Q9C0I9
    Related
    ENSP00000342641.5, ENST00000344079.9
    Conserved Domains (4) summary
    cd00116
    Location:50150
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  4. NM_001309474.2NP_001296403.1  leucine-rich repeat-containing protein 27 isoform d

    See identical proteins and their annotated locations for NP_001296403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in both UTRs, uses an in-frame downstream start codon, and includes a novel 3' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK301422, BQ775276
    UniProtKB/TrEMBL
    B4DW88
    Conserved Domains (1) summary
    PTZ00121
    Location:205341
    PTZ00121; MAEBL; Provisional
  5. NM_030626.3NP_085129.1  leucine-rich repeat-containing protein 27 isoform a

    See identical proteins and their annotated locations for NP_085129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB051461, AL512722, AL590105, DA658738
    Consensus CDS
    CCDS31316.1
    UniProtKB/Swiss-Prot
    Q8NA21, Q9C0I9
    UniProtKB/TrEMBL
    A0A140VJN2
    Related
    ENSP00000357603.3, ENST00000368614.8
    Conserved Domains (4) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12302
    Location:331471
    DUF3629; Protein of unknown function (DUF3629)
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132330063..132381508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540208.2XP_011538510.1  leucine-rich repeat-containing protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011538510.1

    UniProtKB/Swiss-Prot
    Q8NA21, Q9C0I9
    UniProtKB/TrEMBL
    A0A140VJN2
    Conserved Domains (4) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12302
    Location:331471
    DUF3629; Protein of unknown function (DUF3629)
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  2. XM_047425785.1XP_047281741.1  leucine-rich repeat-containing protein 27 isoform X1

    UniProtKB/Swiss-Prot
    Q8NA21
    UniProtKB/TrEMBL
    A0A140VJN2
  3. XM_047425786.1XP_047281742.1  leucine-rich repeat-containing protein 27 isoform X1

    UniProtKB/Swiss-Prot
    Q8NA21
    UniProtKB/TrEMBL
    A0A140VJN2
  4. XM_047425787.1XP_047281743.1  leucine-rich repeat-containing protein 27 isoform X2

  5. XM_047425788.1XP_047281744.1  leucine-rich repeat-containing protein 27 isoform X4

  6. XM_024448208.2XP_024303976.1  leucine-rich repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
    cl26511
    Location:225478
    Neuromodulin_N; Gap junction protein N-terminal region
  7. XM_011540209.3XP_011538511.1  leucine-rich repeat-containing protein 27 isoform X2

    Conserved Domains (4) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12302
    Location:331471
    DUF3629; Protein of unknown function (DUF3629)
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  8. XM_006717984.4XP_006718047.1  leucine-rich repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
    cl26511
    Location:225478
    Neuromodulin_N; Gap junction protein N-terminal region
  9. XM_047425789.1XP_047281745.1  leucine-rich repeat-containing protein 27 isoform X5

  10. XM_017016690.3XP_016872179.1  leucine-rich repeat-containing protein 27 isoform X3

  11. XM_047425793.1XP_047281749.1  leucine-rich repeat-containing protein 27 isoform X8

  12. XM_047425791.1XP_047281747.1  leucine-rich repeat-containing protein 27 isoform X8

  13. XM_047425792.1XP_047281748.1  leucine-rich repeat-containing protein 27 isoform X8

  14. XM_047425794.1XP_047281750.1  leucine-rich repeat-containing protein 27 isoform X9

  15. XM_047425790.1XP_047281746.1  leucine-rich repeat-containing protein 27 isoform X6

  16. XM_017016692.3XP_016872181.1  leucine-rich repeat-containing protein 27 isoform X8

    UniProtKB/Swiss-Prot
    Q9C0I9
    Conserved Domains (4) summary
    cd00116
    Location:50150
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:4968
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:67108
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:67126
    LRR_8; Leucine rich repeat
  17. XM_017016693.3XP_016872182.1  leucine-rich repeat-containing protein 27 isoform X9

  18. XM_017016691.3XP_016872180.1  leucine-rich repeat-containing protein 27 isoform X6

  19. XM_011540210.4XP_011538512.1  leucine-rich repeat-containing protein 27 isoform X7

    Related
    ENSP00000357601.1, ENST00000368612.3
    Conserved Domains (1) summary
    pfam12302
    Location:204344
    DUF3629; Protein of unknown function (DUF3629)

RNA

  1. XR_001747213.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133274838..133327017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)