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TET1 tet methylcytosine dioxygenase 1 [ Homo sapiens (human) ]

Gene ID: 80312, updated on 24-May-2020

Summary

Official Symbol
TET1provided by HGNC
Official Full Name
tet methylcytosine dioxygenase 1provided by HGNC
Primary source
HGNC:HGNC:29484
See related
Ensembl:ENSG00000138336 MIM:607790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCX; CXXC6; bA119F7.1
Summary
DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TET1 in Genome Data Viewer
Location:
10q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (68560337..68700794)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70320117..70454239)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 16 Neighboring gene Sharpr-MPRA regulatory region 5966 Neighboring gene transmembrane protein 14D, pseudogene Neighboring gene COX20 pseudogene 1 Neighboring gene RPS3A pseudogene 37 Neighboring gene cell division cycle and apoptosis regulator 1 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene RNA, U6 small nuclear 697, pseudogene Neighboring gene storkhead box 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10839, FLJ41442, KIAA1676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylcytosine dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
methylcytosine dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
inner cell mass cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of methylation-dependent chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
methylcytosine dioxygenase TET1
Names
CXXC finger 6
CXXC zinc finger 6
CXXC-type zinc finger protein 6
TET1 splice variant VP_DE4
TET1 splice variant VP_DE456
leukemia-associated protein with a CXXC domain
ten-eleven translocation 1 gene protein
ten-eleven translocation-1
tet oncogene 1
NP_085128.2
XP_011538506.1
XP_011538507.1
XP_011538508.1
XP_011538509.1
XP_016872175.1
XP_016872176.1
XP_016872177.1
XP_016872178.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030625.3NP_085128.2  methylcytosine dioxygenase TET1

    See identical proteins and their annotated locations for NP_085128.2

    Status: REVIEWED

    Source sequence(s)
    AF430147, AK123436, AL513534, AL713888, AL832334
    Consensus CDS
    CCDS7281.1
    UniProtKB/Swiss-Prot
    Q8NFU7
    Related
    ENSP00000362748.4, ENST00000373644.5
    Conserved Domains (3) summary
    pfam02008
    Location:585624
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:15801707
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:10351057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    68560337..68700794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540204.2XP_011538506.1  methylcytosine dioxygenase TET1 isoform X1

    Conserved Domains (3) summary
    pfam02008
    Location:585624
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:15801736
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:10351057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions
  2. XM_011540206.2XP_011538508.1  methylcytosine dioxygenase TET1 isoform X5

    Conserved Domains (2) summary
    pfam02008
    Location:585624
    zf-CXXC; CXXC zinc finger domain
    cl05674
    Location:10351057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions
  3. XM_017016688.1XP_016872177.1  methylcytosine dioxygenase TET1 isoform X4

  4. XM_017016689.1XP_016872178.1  methylcytosine dioxygenase TET1 isoform X6

    Conserved Domains (2) summary
    pfam12851
    Location:9091065
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:364386
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions
  5. XM_017016687.1XP_016872176.1  methylcytosine dioxygenase TET1 isoform X4

  6. XM_011540207.2XP_011538509.1  methylcytosine dioxygenase TET1 isoform X6

    Conserved Domains (2) summary
    pfam12851
    Location:9091065
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:364386
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions
  7. XM_011540205.2XP_011538507.1  methylcytosine dioxygenase TET1 isoform X2

    Conserved Domains (2) summary
    pfam12851
    Location:9431099
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:398420
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions
  8. XM_017016686.2XP_016872175.1  methylcytosine dioxygenase TET1 isoform X3

RNA

  1. XR_001747211.1 RNA Sequence

  2. XR_001747212.1 RNA Sequence

  3. XR_001747210.1 RNA Sequence

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