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TET1 tet methylcytosine dioxygenase 1 [ Homo sapiens (human) ]

Gene ID: 80312, updated on 10-Mar-2023

Summary

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Official Symbol
TET1provided by HGNC
Official Full Name
tet methylcytosine dioxygenase 1provided by HGNC
Primary source
HGNC:HGNC:29484
See related
Ensembl:ENSG00000138336 MIM:607790; AllianceGenome:HGNC:29484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCX; CXXC6; bA119F7.1
Summary
DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See TET1 in Genome Data Viewer
Location:
10q21.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (68560337..68694487)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (69429559..69563685)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70320094..70454244)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 16 Neighboring gene Sharpr-MPRA regulatory region 5966 Neighboring gene transmembrane protein 14D, pseudogene Neighboring gene COX20 pseudogene 1 Neighboring gene RPS3A pseudogene 37 Neighboring gene small nucleolar RNA U13 Neighboring gene cell division cycle and apoptosis regulator 1 Neighboring gene small nucleolar RNA, C/D box 98

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant high expression of the TET1 gene in Hirschsprung's disease. Yang S, et al. Pediatr Neonatol, 2022 Jul. PMID 35650007
  2. Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1. Zhu T, et al. Genes (Basel), 2022 May 14. PMID 35627266, Free PMC Article
  3. Assessment of TET1 gene expression, DNA methylation and H3K27me3 level of its promoter region in eutopic endometrium of women with endometriosis and infertility. Adamczyk M, et al. Biomed Pharmacother, 2022 Jun. PMID 35489280
  4. TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma. Qiu T, et al. World J Surg Oncol, 2022 Apr 8. PMID 35395805, Free PMC Article
  5. Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature. Schagdarsurengin U, et al. Clin Epigenetics, 2021 Nov 29. PMID 34844636, Free PMC Article

See all (208) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TET1-mediated microRNA-188-5p promoter hydroxymethylation regulates PTEN/PI3K/AKT signaling pathway in acute myeloid leukemia cells.
    Title: TET1-mediated microRNA-188-5p promoter hydroxymethylation regulates PTEN/PI3K/AKT signaling pathway in acute myeloid leukemia cells.
  2. High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications.
    Title: High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications.
  3. DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
    Title: DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
  4. MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
    Title: MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
  5. Competitive binding of TET1 and DNMT3A/B cooperates the DNA methylation pattern in human embryonic stem cells.
    Title: Competitive binding of TET1 and DNMT3A/B cooperates the DNA methylation pattern in human embryonic stem cells.
  6. Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
    Title: Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
  7. YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis.
    Title: YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis.
  8. TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.
    Title: TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.
  9. Aberrant high expression of the TET1 gene in Hirschsprung's disease.
    Title: Aberrant high expression of the TET1 gene in Hirschsprung's disease.
  10. Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1.
    Title: Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1.
Submit: New GeneRIF Correction See all GeneRIFs (183)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10839, FLJ41442, KIAA1676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables methylcytosine dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylcytosine dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5-methylcytosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in DNA demethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in inner cell mass cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Sin3 complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
methylcytosine dioxygenase TET1
Names
CXXC finger 6
CXXC zinc finger 6
CXXC-type zinc finger protein 6
leukemia-associated protein with a CXXC domain
ten-eleven translocation 1 gene protein
ten-eleven translocation-1
tet oncogene 1
NP_085128.2
XP_011538506.1
XP_011538507.1
XP_011538508.1
XP_016872175.1
XP_016872176.1
XP_016872177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406365.1 → NP_001393294.1  methylcytosine dioxygenase TET1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  2. NM_001406367.1 → NP_001393296.1  methylcytosine dioxygenase TET1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  3. NM_001406368.1 → NP_001393297.1  methylcytosine dioxygenase TET1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  4. NM_001406369.1 → NP_001393298.1  methylcytosine dioxygenase TET1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  5. NM_001406370.1 → NP_001393299.1  methylcytosine dioxygenase TET1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  6. NM_001406371.1 → NP_001393300.1  methylcytosine dioxygenase TET1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  7. NM_001406372.1 → NP_001393301.1  methylcytosine dioxygenase TET1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  8. NM_001406373.1 → NP_001393302.1  methylcytosine dioxygenase TET1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  9. NM_001406374.1 → NP_001393303.1  methylcytosine dioxygenase TET1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  10. NM_001406375.1 → NP_001393304.1  methylcytosine dioxygenase TET1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  11. NM_001406376.1 → NP_001393305.1  methylcytosine dioxygenase TET1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL513534, AL713888

  12. NM_030625.3 → NP_085128.2  methylcytosine dioxygenase TET1 isoform 2

    See identical proteins and their annotated locations for NP_085128.2

    Status: REVIEWED

    Source sequence(s)
    AF430147, AK123436, AL513534, AL713888, AL832334
    Consensus CDS
    CCDS7281.1
    UniProtKB/Swiss-Prot
    Q8NFU7, Q9C0I7
    Related
    ENSP00000362748.4, ENST00000373644.5
    Conserved Domains (3) summary
    pfam02008
    Location:585 → 624
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1580 → 1707
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:1035 → 1057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    68560337..68694487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540204.3 → XP_011538506.1  methylcytosine dioxygenase TET1 isoform X1

    Conserved Domains (3) summary
    pfam02008
    Location:585 → 624
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1580 → 1736
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:1035 → 1057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions

  2. XM_011540206.3 → XP_011538508.1  methylcytosine dioxygenase TET1 isoform X5

    Conserved Domains (2) summary
    pfam02008
    Location:585 → 624
    zf-CXXC; CXXC zinc finger domain
    cl05674
    Location:1035 → 1057
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions

  3. XM_017016688.2 → XP_016872177.1  methylcytosine dioxygenase TET1 isoform X4

  4. XM_011540205.3 → XP_011538507.1  methylcytosine dioxygenase TET1 isoform X2

    Conserved Domains (2) summary
    pfam12851
    Location:943 → 1099
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    cl05674
    Location:398 → 420
    PET; PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions

  5. XM_017016687.2 → XP_016872176.1  methylcytosine dioxygenase TET1 isoform X4

  6. XM_017016686.3 → XP_016872175.1  methylcytosine dioxygenase TET1 isoform X3

RNA

  1. XR_001747211.2 RNA Sequence

  2. XR_001747212.2 RNA Sequence

  3. XR_001747210.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    69429559..69563685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFU7.2 GenPept UniProtKB/Swiss-Prot:Q8NFU7

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