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SPHKAP SPHK1 interactor, AKAP domain containing [ Homo sapiens (human) ]

Gene ID: 80309, updated on 23-Nov-2021

Summary

Official Symbol
SPHKAPprovided by HGNC
Official Full Name
SPHK1 interactor, AKAP domain containingprovided by HGNC
Primary source
HGNC:HGNC:30619
See related
Ensembl:ENSG00000153820 MIM:611646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKIP
Expression
Biased expression in heart (RPKM 11.8), brain (RPKM 8.0) and 1 other tissue See more
Orthologs
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Genomic context

See SPHKAP in Genome Data Viewer
Location:
2q36.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (227979954..228181999, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (228844671..229046403, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 2 Neighboring gene dynein assembly factor with WD repeats 1 Neighboring gene uncharacterized LOC105373918 Neighboring gene uncharacterized LOC107985993 Neighboring gene RNA, U6 small nuclear 624, pseudogene Neighboring gene SNF8 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1807 Neighboring gene uncharacterized LOC105373921

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1678, MGC132614, MGC132616, DKFZp781H143, DKFZp781J171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase A binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein SPHKAP
Names
SPHK1 (sphingosine kinase type 1) interacting protein
SPHK1-interactor and AKAP domain-containing protein
sphingosine kinase type 1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142644.2NP_001136116.1  A-kinase anchor protein SPHKAP isoform 1

    See identical proteins and their annotated locations for NP_001136116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB051465, AC109825, AK095042, BC104956
    Consensus CDS
    CCDS46537.1
    UniProtKB/Swiss-Prot
    Q2M3C7
    Related
    ENSP00000375909.3, ENST00000392056.8
    Conserved Domains (1) summary
    cl14906
    Location:15971697
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  2. NM_030623.4NP_085126.2  A-kinase anchor protein SPHKAP isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2) than isoform 1.
    Source sequence(s)
    AB051465, AC109825, AK095042, AK127071, BC104954, CR749494
    Consensus CDS
    CCDS33389.1
    UniProtKB/Swiss-Prot
    Q2M3C7
    Related
    ENSP00000339886.5, ENST00000344657.5
    Conserved Domains (1) summary
    cl14906
    Location:15681668
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    227979954..228181999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712777.3XP_006712840.1  A-kinase anchor protein SPHKAP isoform X1

    Conserved Domains (1) summary
    cl14906
    Location:16221722
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  2. XM_005246870.4XP_005246927.1  A-kinase anchor protein SPHKAP isoform X4

    Conserved Domains (1) summary
    cl14906
    Location:15801680
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  3. XM_011511925.2XP_011510227.1  A-kinase anchor protein SPHKAP isoform X2

    See identical proteins and their annotated locations for XP_011510227.1

    Conserved Domains (1) summary
    cl14906
    Location:16121712
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  4. XM_006712778.4XP_006712841.1  A-kinase anchor protein SPHKAP isoform X3

    Conserved Domains (1) summary
    cl14906
    Location:15931693
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
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