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TRABD TraB domain containing [ Homo sapiens (human) ]

Gene ID: 80305, updated on 1-Jun-2020

Summary

Official Symbol
TRABDprovided by HGNC
Official Full Name
TraB domain containingprovided by HGNC
Primary source
HGNC:HGNC:28805
See related
Ensembl:ENSG00000170638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP6054; PP2447
Expression
Ubiquitous expression in bone marrow (RPKM 19.6), spleen (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See TRABD in Genome Data Viewer
Location:
22q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50185889..50199599)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50624344..50638027)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Mov10 like RISC complex RNA helicase 1 Neighboring gene pannexin 2 Neighboring gene uncharacterized LOC105373095 Neighboring gene selenoprotein O Neighboring gene tubulin gamma complex associated protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110928

General protein information

Preferred Names
traB domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320484.2NP_001307413.1  traB domain-containing protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL449244, BU902575, CF272467
    UniProtKB/Swiss-Prot
    Q9H4I3
    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  2. NM_001320485.2NP_001307414.1  traB domain-containing protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AL449244, BU902575
    Consensus CDS
    CCDS14086.1
    UniProtKB/Swiss-Prot
    Q9H4I3
    Related
    ENSP00000370295.4, ENST00000380909.8
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  3. NM_001320487.2NP_001307416.1  traB domain-containing protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AL449244, HY033228
    Consensus CDS
    CCDS14086.1
    UniProtKB/Swiss-Prot
    Q9H4I3
    Related
    ENSP00000379171.1, ENST00000395827.5
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  4. NM_001320488.2NP_001307417.1  traB domain-containing protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice junction, and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL022328, AL449244, BI907868, BX389277, BX417817, HY033228
    Consensus CDS
    CCDS82724.1
    UniProtKB/Swiss-Prot
    Q9H4I3
    UniProtKB/TrEMBL
    J3KPT4
    Related
    ENSP00000379173.1, ENST00000395829.1
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  5. NM_001378762.1NP_001365691.1  traB domain-containing protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AL022328
  6. NM_001378765.1NP_001365694.1  traB domain-containing protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL022328
  7. NM_025204.4NP_079480.2  traB domain-containing protein isoform b

    See identical proteins and their annotated locations for NP_079480.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AL449244, BU902575
    Consensus CDS
    CCDS14086.1
    UniProtKB/Swiss-Prot
    Q9H4I3
    Related
    ENSP00000305664.4, ENST00000303434.8
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family

RNA

  1. NR_135275.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL022328, AL449244, BU902575, BX425224

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50185889..50199599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530716.2XP_011529018.1  traB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011529018.1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  2. XM_006724423.3XP_006724486.1  traB domain-containing protein isoform X4

    See identical proteins and their annotated locations for XP_006724486.1

    UniProtKB/TrEMBL
    J3KPT4
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  3. XM_011530717.2XP_011529019.1  traB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011529019.1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  4. XM_006724422.3XP_006724485.1  traB domain-containing protein isoform X4

    See identical proteins and their annotated locations for XP_006724485.1

    UniProtKB/TrEMBL
    J3KPT4
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  5. XM_011530718.2XP_011529020.1  traB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011529020.1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  6. XM_024452272.1XP_024308040.1  traB domain-containing protein isoform X1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  7. XM_011530715.2XP_011529017.2  traB domain-containing protein isoform X3

  8. XM_011530712.2XP_011529014.2  traB domain-containing protein isoform X1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  9. XM_011530713.3XP_011529015.2  traB domain-containing protein isoform X2

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family
  10. XM_017028944.1XP_016884433.1  traB domain-containing protein isoform X5

    UniProtKB/Swiss-Prot
    Q9H4I3
    Conserved Domains (1) summary
    cl12050
    Location:62275
    TraB; TraB family
  11. XM_017028943.1XP_016884432.1  traB domain-containing protein isoform X1

    Conserved Domains (1) summary
    cl12050
    Location:62279
    TraB; TraB family

RNA

  1. XR_002958713.1 RNA Sequence

    Related
    ENST00000463233.1
  2. XR_001755302.1 RNA Sequence

  3. XR_938345.2 RNA Sequence

  4. XR_001755303.2 RNA Sequence

  5. XR_938346.3 RNA Sequence

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