Abtb1 ankyrin repeat and BTB (POZ) domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abtb1provided by MGI
Official Full Name: ankyrin repeat and BTB (POZ) domain containing 1provided by MGI
Primary source: MGI:MGI:1933148
See related: Ensembl:ENSMUSG00000030083 AllianceGenome:MGI:1933148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BPOZ; EF1ABP
Summary: Predicted to enable translation elongation factor activity. Predicted to act upstream of or within translational elongation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; sensory organ; and skeleton. Orthologous to human ABTB1 (ankyrin repeat and BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 35.2), ovary adult (RPKM 26.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 D1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (88812896..88819356, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (88835914..88842375, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway.
Title: Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Abtb1 (e-PCR), detects polymorphism
- UniSTS:547421

AI847549 (e-PCR)
- UniSTS:164332

Homology

Homologs of the Abtb1 gene: The Abtb1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Abtb1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: ankyrin repeat and BTB/POZ domain-containing protein 1

Names: mFLJ00331 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362152.2 → NP_001349081.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC153923

Conserved Domains (3) summary

cd18296
Location:112 → 235

BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18497
Location:234 → 305

BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cl38908
Location:1 → 72

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
NM_001411474.1 → NP_001398403.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411475.1 → NP_001398404.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411476.1 → NP_001398405.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411477.1 → NP_001398406.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411478.1 → NP_001398407.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411479.1 → NP_001398408.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411480.1 → NP_001398409.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411481.1 → NP_001398410.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411482.1 → NP_001398411.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC153923
NM_001411483.1 → NP_001398412.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC153923
NM_030251.4 → NP_084527.2 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_084527.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC153923

Consensus CDS

CCDS20339.1

UniProtKB/Swiss-Prot

Q99LJ2

UniProtKB/TrEMBL

A0A0R4J0A1

Related

ENSMUSP00000032169.6, ENSMUST00000032169.8

Conserved Domains (5) summary

smart00225
Location:273 → 376

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:6 → 76

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00651
Location:105 → 210

BTB; BTB/POZ domain

pfam13857
Location:21 → 76

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:35 → 60

ANK; ANK repeat [structural motif]

RNA

NR_155424.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC153923

Related

ENSMUST00000203137.3
NR_177267.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153923
NR_177268.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153923
NR_177269.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153923
NR_177270.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153923
NR_177272.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153923

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

88812896..88819356 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506791.4 → XP_006506854.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1

Conserved Domains (3) summary

cd18295
Location:88 → 205

BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18296
Location:245 → 368

BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18497
Location:367 → 438

BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
XM_030255681.2 → XP_030111541.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X3

Conserved Domains (3) summary

cd18296
Location:112 → 235

BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18497
Location:234 → 305

BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cl38908
Location:1 → 72

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_030255680.2 → XP_030111540.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X3

Conserved Domains (3) summary

cd18296
Location:112 → 235

BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18497
Location:234 → 305

BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cl38908
Location:1 → 72

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006506792.5 → XP_006506855.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X2

Conserved Domains (5) summary

sd00045
Location:35 → 60

ANK; ANK repeat [structural motif]

cd18295
Location:97 → 214

BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cl38908
Location:254 → 344

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam12796
Location:6 → 65

Ank_2; Ankyrin repeats (3 copies)

cl28903
Location:343 → 380

BACK; BACK (BTB and C-terminal Kelch) domain
XM_006506793.4 → XP_006506856.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X3

Conserved Domains (3) summary

cd18296
Location:112 → 235

BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cd18497
Location:234 → 305

BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

cl38908
Location:1 → 72

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily