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MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor [ Homo sapiens (human) ]

Gene ID: 8028, updated on 29-Mar-2023

Summary

Official Symbol
MLLT10provided by HGNC
Official Full Name
MLLT10 histone lysine methyltransferase DOT1L cofactorprovided by HGNC
Primary source
HGNC:HGNC:16063
See related
Ensembl:ENSG00000078403 MIM:602409; AllianceGenome:HGNC:16063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF10
Summary
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Broad expression in testis (RPKM 40.9), ovary (RPKM 8.6) and 23 other tissues See more
Orthologs
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Genomic context

See MLLT10 in Genome Data Viewer
Location:
10p12.31
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (21533756..21743630)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (21552866..21762703)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (21822685..22032559)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21814647-21815290 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:21817867-21818510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21822730-21823443 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:21824159-21824871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21825135-21825648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21844418-21845000 Neighboring gene RNA, U6 small nuclear 306, pseudogene Neighboring gene solute carrier family 4 member 8 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:21952461-21953111 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:21954039-21954538 Neighboring gene RNA, U6 small nuclear 1141, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:21999974-22000474 Neighboring gene NANOG hESC enhancer GRCh37_chr10:22015451-22015952 Neighboring gene uncharacterized LOC107984214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:22036939-22037438 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:22039902-22041101

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variation at 10p12.31 near MLLT10 influences meningioma risk.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC75086, DKFZp686E10210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein AF-10
Names
ALL1-fused gene from chromosome 10 protein
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
type I AF10 protein
type III AF10 protein
type IV AF10 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027818.2 RefSeqGene

    Range
    5061..214459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195626.3NP_001182555.1  protein AF-10 isoform c

    See identical proteins and their annotated locations for NP_001182555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. The resulting protein (isoform c) is longer than isoform a.
    Source sequence(s)
    AL161799, AL357372, AL358780, AL359697
    Consensus CDS
    CCDS55708.1
    UniProtKB/Swiss-Prot
    P55197, Q66K63
    UniProtKB/TrEMBL
    Q59EQ6, Q6N002
    Related
    ENSP00000307411.7, ENST00000307729.12
    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  2. NM_001195627.2NP_001182556.1  protein AF-10 isoform d

    See identical proteins and their annotated locations for NP_001182556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift and early stop codon. The resulting protein (isoform d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BC032532, BC080577, BC094844
    Consensus CDS
    CCDS55706.1
    UniProtKB/Swiss-Prot
    P55197
    Related
    ENSP00000366295.2, ENST00000377091.7
    Conserved Domains (1) summary
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
  3. NM_001195628.2NP_001182557.1  protein AF-10 isoform e

    See identical proteins and their annotated locations for NP_001182557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift and early stop codon. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a. Variants 5, 6, and 7 all encode the same isoform (e).
    Source sequence(s)
    BC032532, BC052798, BC094844
    Consensus CDS
    CCDS55707.1
    UniProtKB/Swiss-Prot
    P55197
    Related
    ENSP00000498595.1, ENST00000652497.1
    Conserved Domains (1) summary
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
  4. NM_001195630.2NP_001182559.1  protein AF-10 isoform e

    See identical proteins and their annotated locations for NP_001182559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift and early stop codon. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a. Variants 5, 6, and 7 all encode the same isoform (e).
    Source sequence(s)
    BC032532, BC094844
    Consensus CDS
    CCDS55707.1
    UniProtKB/Swiss-Prot
    P55197
    Related
    ENSP00000366304.3, ENST00000377100.8
    Conserved Domains (1) summary
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
  5. NM_001324296.2NP_001311225.1  protein AF-10 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform e.
    Source sequence(s)
    AL358780
    Consensus CDS
    CCDS55707.1
    UniProtKB/Swiss-Prot
    P55197
    Conserved Domains (1) summary
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
  6. NM_001324297.2NP_001311226.1  protein AF-10 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL161799, AL357372, AL358780, AL359697
    Related
    ENSP00000408281.2, ENST00000438473.6
  7. NM_004641.4NP_004632.1  protein AF-10 isoform a

    See identical proteins and their annotated locations for NP_004632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB209755, BC032532, BX640774, U13948
    Consensus CDS
    CCDS7135.1
    UniProtKB/Swiss-Prot
    P55197
    UniProtKB/TrEMBL
    Q59EQ6, Q6N002
    Related
    ENSP00000366272.3, ENST00000377072.8
    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

RNA

  1. NR_136736.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB209755, AL358780, AL359697
    Related
    ENST00000651298.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    21533756..21743630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    21552866..21762703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009569.1: Suppressed sequence

    Description
    NM_001009569.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.