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ELL3 elongation factor for RNA polymerase II 3 [ Homo sapiens (human) ]

Gene ID: 80237, updated on 5-Aug-2022

Summary

Official Symbol
ELL3provided by HGNC
Official Full Name
elongation factor for RNA polymerase II 3provided by HGNC
Primary source
HGNC:HGNC:23113
See related
Ensembl:ENSG00000128886 MIM:609885; AllianceGenome:HGNC:23113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in several cellular components, including chromosome; cytosol; and nuclear lumen. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 75.8), prostate (RPKM 58.8) and 25 other tissues See more
Orthologs
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Genomic context

See ELL3 in Genome Data Viewer
Location:
15q15.3
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43772620..43776966, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41579980..41584326, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44064818..44069164, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 354, pseudogene Neighboring gene cation channel sperm associated 2 pseudogene 1 Neighboring gene protein disulfide isomerase family A member 3 Neighboring gene small EDRK-rich factor 2 Neighboring gene SERF2-C15orf63 readthrough Neighboring gene microRNA 1282 Neighboring gene serine incorporator 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription elongation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in snRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription elongation by RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription elongation factor complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
RNA polymerase II elongation factor ELL3
Names
elongation factor RNA polymerase II-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025165.3NP_079441.1  RNA polymerase II elongation factor ELL3

    See identical proteins and their annotated locations for NP_079441.1

    Status: VALIDATED

    Source sequence(s)
    AC018512, AK126384
    Consensus CDS
    CCDS10102.1
    UniProtKB/Swiss-Prot
    Q9H634, Q9HB65
    Related
    ENSP00000320346.3, ENST00000319359.8
    Conserved Domains (2) summary
    pfam07303
    Location:291391
    Occludin_ELL; Occludin homology domain
    pfam10390
    Location:17118
    ELL; RNA polymerase II elongation factor ELL

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43772620..43776966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41579980..41584326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)