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WDR26 WD repeat domain 26 [ Homo sapiens (human) ]

Gene ID: 80232, updated on 17-Jun-2019

Summary

Official Symbol
WDR26provided by HGNC
Official Full Name
WD repeat domain 26provided by HGNC
Primary source
HGNC:HGNC:21208
See related
Ensembl:ENSG00000162923 MIM:617424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDW2; GID7; MIP2; SKDEAS
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 30.1), esophagus (RPKM 28.6) and 25 other tissues See more
Orthologs

Genomic context

See WDR26 in Genome Data Viewer
Location:
1q42.11-q42.12
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (224385143..224434797, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (224572845..224622001, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12366 Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene microRNA 4742 Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene aldehyde reductase family 1 member B1 pseudogene 1 Neighboring gene uncharacterized LOC102723817

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
SKRABAN-DEARDORFF SYNDROME
MedGen: C4539927 OMIM: 617616 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 26
Names
CUL4- and DDB1-associated WDR protein 2
GID complex subunit 7 homolog
myocardial ischemic preconditioning upregulated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047198.1 RefSeqGene

    Range
    5001..54157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001115113.3NP_001108585.2  WD repeat-containing protein 26 isoform b

    See identical proteins and their annotated locations for NP_001108585.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC099790, AY221751, BF509638, BU673957, CN283908
    UniProtKB/Swiss-Prot
    Q9H7D7
    Conserved Domains (3) summary
    smart00668
    Location:156215
    CTLH; C-terminal to LisH motif
    cd00200
    Location:333625
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:343383
    7WD40; WD40 repeat [structural motif]
  2. NM_025160.6NP_079436.4  WD repeat-containing protein 26 isoform a

    See identical proteins and their annotated locations for NP_079436.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB209887, AC099790, BU673957, CN283908
    Consensus CDS
    CCDS31037.2
    UniProtKB/Swiss-Prot
    Q9H7D7
    Related
    ENSP00000498603.1, ENST00000651911.1
    Conserved Domains (3) summary
    smart00668
    Location:156231
    CTLH; C-terminal to LisH motif
    cd00200
    Location:349641
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:359399
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    224385143..224434797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711817.4XP_006711880.1  WD repeat-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006711880.1

    Conserved Domains (3) summary
    smart00668
    Location:156231
    CTLH; C-terminal to LisH motif
    cd00200
    Location:348640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:358398
    7WD40; WD40 repeat [structural motif]
  2. XM_005273273.5XP_005273330.1  WD repeat-containing protein 26 isoform X2

    See identical proteins and their annotated locations for XP_005273330.1

    Conserved Domains (3) summary
    smart00668
    Location:156231
    CTLH; C-terminal to LisH motif
    sd00039
    Location:359399
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:349592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011544281.2XP_011542583.1  WD repeat-containing protein 26 isoform X3

    See identical proteins and their annotated locations for XP_011542583.1

    Conserved Domains (3) summary
    COG2319
    Location:136431
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:139431
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:149189
    7WD40; WD40 repeat [structural motif]
  4. XM_017002396.1XP_016857885.1  WD repeat-containing protein 26 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:136431
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:139431
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:149189
    7WD40; WD40 repeat [structural motif]
  5. XM_011544282.2XP_011542584.1  WD repeat-containing protein 26 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:89384
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:92384
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:102142
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_001737437.2 RNA Sequence

  2. XR_002957643.1 RNA Sequence

  3. XR_002957642.1 RNA Sequence

  4. XR_002957644.1 RNA Sequence

  5. XR_247043.4 RNA Sequence

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