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HKDC1 hexokinase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 80201, updated on 6-Sep-2021

Summary

Official Symbol
HKDC1provided by HGNC
Official Full Name
hexokinase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23302
See related
Ensembl:ENSG00000156510 MIM:617221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]
Expression
Biased expression in duodenum (RPKM 22.5), small intestine (RPKM 21.3) and 6 other tissues See more
Orthologs
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Genomic context

See HKDC1 in Genome Data Viewer
Location:
10q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (69220303..69267552)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70980088..71027308)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene VPS26, retromer complex component A Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene Suv3 like RNA helicase Neighboring gene uncharacterized LOC101928994 Neighboring gene hexokinase 1 Neighboring gene ribosomal protein S15a pseudogene 28 Neighboring gene tachykinin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of hexokinase domain containing 1 (HKDC1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22761, FLJ37767, MGC125688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hexokinase HKDC1
Names
hexokinase domain-containing protein 1
putative hexokinase HKDC1
NP_079406.4
XP_011538497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051555.1 RefSeqGene

    Range
    5001..52257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025130.4NP_079406.4  hexokinase HKDC1

    Status: REVIEWED

    Source sequence(s)
    AL596223
    Consensus CDS
    CCDS7288.1
    Related
    ENSP00000346643.5, ENST00000354624.6
    Conserved Domains (3) summary
    PLN02914
    Location:26462
    PLN02914; hexokinase
    PTZ00107
    Location:466907
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:21219
    Hexokinase_1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    69220303..69267552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540195.2XP_011538497.1  hexokinase HKDC1 isoform X1

    Conserved Domains (3) summary
    PLN02914
    Location:26462
    PLN02914; hexokinase
    pfam00349
    Location:469666
    Hexokinase_1
    pfam03727
    Location:672738
    Hexokinase_2

RNA

  1. XR_001747209.1 RNA Sequence

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