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RNF34 ring finger protein 34 [ Homo sapiens (human) ]

Gene ID: 80196, updated on 31-Dec-2019

Summary

Official Symbol
RNF34provided by HGNC
Official Full Name
ring finger protein 34provided by HGNC
Primary source
HGNC:HGNC:17297
See related
Ensembl:ENSG00000170633 MIM:608299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFI; RIF; RIFF; hRFI; CARP1; CARP-1
Summary
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See RNF34 in Genome Data Viewer
Location:
12q24.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (121400083..121424352)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121837886..121862155)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent protein kinase kinase 2 Neighboring gene anaphase promoting complex subunit 5 Neighboring gene lysine demethylase 2B Neighboring gene microRNA 7107 Neighboring gene uncharacterized LOC105370033 Neighboring gene KDM2B divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF34
Names
FYVE-RING finger protein MOMO
RING finger protein RIFF
RING-type E3 ubiquitin transferase RNF34
caspase regulator CARP1
caspases-8 and -10-associated RING finger protein 1
human RING finger homologous to inhibitor of apoptosis protein
ring finger protein 34, E3 ubiquitin protein ligase
NP_001243787.1
NP_079402.2
NP_919247.1
XP_024304958.1
XP_024304959.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256858.1NP_001243787.1  E3 ubiquitin-protein ligase RNF34 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region which results in the use of an alternate translational start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    AK025439, BI559962, DB242808
    Consensus CDS
    CCDS73538.1
    UniProtKB/Swiss-Prot
    Q969K3
    UniProtKB/TrEMBL
    A0A087WTM5
    Related
    ENSP00000477987.1, ENST00000613529.4
    Conserved Domains (1) summary
    pfam13920
    Location:129171
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_025126.3NP_079402.2  E3 ubiquitin-protein ligase RNF34 isoform 2

    See identical proteins and their annotated locations for NP_079402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of an alternate translational start codon, compared to variant 1. The resulting isoform (2) lacks one amino acid in the N-terminus, compared isoform 1.
    Source sequence(s)
    AF306709, AK025439
    Consensus CDS
    CCDS31915.1
    UniProtKB/Swiss-Prot
    Q969K3
    Related
    ENSP00000355137.5, ENST00000361234.9
    Conserved Domains (2) summary
    cd15769
    Location:59105
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:324362
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins
  3. NM_194271.2NP_919247.1  E3 ubiquitin-protein ligase RNF34 isoform 1

    See identical proteins and their annotated locations for NP_919247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF306709, AK025439, DA887995
    Consensus CDS
    CCDS9221.1
    UniProtKB/Swiss-Prot
    Q969K3
    Related
    ENSP00000376258.3, ENST00000392465.7
    Conserved Domains (2) summary
    cd15769
    Location:60106
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:325363
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    121400083..121424352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449190.1XP_024304958.1  E3 ubiquitin-protein ligase RNF34 isoform X1

    Conserved Domains (2) summary
    cd15769
    Location:60106
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:325363
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins
  2. XM_024449191.1XP_024304959.1  E3 ubiquitin-protein ligase RNF34 isoform X2

    Conserved Domains (2) summary
    cd15769
    Location:5298
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:317355
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins

RNA

  1. XR_001748871.2 RNA Sequence

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