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RNF34 ring finger protein 34 [ Homo sapiens (human) ]

Gene ID: 80196, updated on 18-Sep-2024

Summary

Official Symbol
RNF34provided by HGNC
Official Full Name
ring finger protein 34provided by HGNC
Primary source
HGNC:HGNC:17297
See related
Ensembl:ENSG00000170633 MIM:608299; AllianceGenome:HGNC:17297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFI; RIF; RIFF; hRFI; CARP1; CARP-1
Summary
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

See RNF34 in Genome Data Viewer
Location:
12q24.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121400118..121424348)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121366860..121415781)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121837921..121862151)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121838561-121839092 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:121838029-121838560 Neighboring gene MPRA-validated peak2014 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7165 Neighboring gene lysine demethylase 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886380-121886880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886881-121887381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121889913-121890727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121890728-121891541 Neighboring gene microRNA 7107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4974 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:121913999-121914826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121925323-121925834 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:121928205-121928918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121937748-121938447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121938448-121939146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121940397-121940896 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121951587-121951880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953080-121953588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953589-121954095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121956373-121956946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121967403-121967904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121971375-121972045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121973358-121974150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121984877-121985582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121987013-121987514 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122014140-122014717 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:122014718-122015296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4977 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122018218-122019153 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122020089-122021024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122021025-122021958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122028863-122029678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122029679-122030494 Neighboring gene KDM2B divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of oxygen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF34
Names
FYVE-RING finger protein MOMO
RING finger protein RIFF
RING-type E3 ubiquitin transferase RNF34
caspase regulator CARP1
caspases-8 and -10-associated RING finger protein 1
human RING finger homologous to inhibitor of apoptosis protein
ring finger protein 34, E3 ubiquitin protein ligase
NP_001243787.1
NP_001381137.1
NP_079402.2
NP_919247.1
XP_024304959.1
XP_047285520.1
XP_054229254.1
XP_054229255.1
XP_054229256.1
XP_054229257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256858.2NP_001243787.1  E3 ubiquitin-protein ligase RNF34 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK025439, BI559962
    Consensus CDS
    CCDS73538.1
    UniProtKB/TrEMBL
    A0A087WTM5
    Related
    ENSP00000477987.1, ENST00000613529.4
    Conserved Domains (1) summary
    pfam13920
    Location:129171
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001394208.1NP_001381137.1  E3 ubiquitin-protein ligase RNF34 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC048337
    Consensus CDS
    CCDS9221.1
    Conserved Domains (2) summary
    cd15769
    Location:60106
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:325363
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins
  3. NM_025126.4NP_079402.2  E3 ubiquitin-protein ligase RNF34 isoform 2

    See identical proteins and their annotated locations for NP_079402.2

    Status: REVIEWED

    Source sequence(s)
    AF306709, AK025439
    Consensus CDS
    CCDS31915.1
    UniProtKB/Swiss-Prot
    B7Z933, Q8NG47, Q969K3, Q9H6W8
    Related
    ENSP00000355137.5, ENST00000361234.10
    Conserved Domains (2) summary
    cd15769
    Location:59105
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:324362
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins
  4. NM_194271.3NP_919247.1  E3 ubiquitin-protein ligase RNF34 isoform 1

    See identical proteins and their annotated locations for NP_919247.1

    Status: REVIEWED

    Source sequence(s)
    AF306709, AK025439, DA887995
    Consensus CDS
    CCDS9221.1
    UniProtKB/Swiss-Prot
    Q969K3
    Related
    ENSP00000376258.3, ENST00000392465.7
    Conserved Domains (2) summary
    cd15769
    Location:60106
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:325363
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins

RNA

  1. NR_172087.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048337

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121400118..121424348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429564.1XP_047285520.1  E3 ubiquitin-protein ligase RNF34 isoform X1

  2. XM_024449191.2XP_024304959.1  E3 ubiquitin-protein ligase RNF34 isoform X1

    Conserved Domains (2) summary
    cd15769
    Location:5298
    FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins
    cd16706
    Location:317355
    RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121366860..121415781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373280.1XP_054229255.1  E3 ubiquitin-protein ligase RNF34 isoform X3

    UniProtKB/Swiss-Prot
    B7Z933, Q8NG47, Q969K3, Q9H6W8
  2. XM_054373279.1XP_054229254.1  E3 ubiquitin-protein ligase RNF34 isoform X2

  3. XM_054373282.1XP_054229257.1  E3 ubiquitin-protein ligase RNF34 isoform X1

  4. XM_054373281.1XP_054229256.1  E3 ubiquitin-protein ligase RNF34 isoform X1