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MYO19 myosin XIX [ Homo sapiens (human) ]

Gene ID: 80179, updated on 2-Mar-2021

Summary

Official Symbol
MYO19provided by HGNC
Official Full Name
myosin XIXprovided by HGNC
Primary source
HGNC:HGNC:26234
See related
Ensembl:ENSG00000278259 MIM:617379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYOHD1
Expression
Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See MYO19 in Genome Data Viewer
Location:
17q12
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36495636..36535338, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34851480..34890695, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371749 Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin light chain binding IEA
Inferred from Electronic Annotation
more info
 
plus-end directed microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion migration along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-XIX
Names
myosin head domain containing 1
myosin head domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033580.3NP_001028752.1  unconventional myosin-XIX isoform 3

    See identical proteins and their annotated locations for NP_001028752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' coding region, 3' UTR, and poly-adenylation signal, compared to variant 2. The resulting isoform (3) has a substantially shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS59283.1
    UniProtKB/Swiss-Prot
    Q96H55
    UniProtKB/TrEMBL
    A0A024R0S9, B7Z1T7
    Related
    ENSP00000477559.1, ENST00000621344.4
    Conserved Domains (1) summary
    cl22853
    Location:49299
    Motor_domain; Myosin and Kinesin motor domain
  2. NM_001163735.2NP_001157207.1  unconventional myosin-XIX isoform 2

    See identical proteins and their annotated locations for NP_001157207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS54112.1
    UniProtKB/Swiss-Prot
    Q96H55
    UniProtKB/TrEMBL
    B4E218, B7Z1T7
    Related
    ENSP00000479518.1, ENST00000614623.4
    Conserved Domains (2) summary
    smart00242
    Location:36754
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49746
    MYSc_Myo19; class XIX myosin, motor domain
  3. NM_025109.6NP_079385.2  unconventional myosin-XIX isoform 1

    See identical proteins and their annotated locations for NP_079385.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame segment, compared to variant 2. The resulting isoform (1) lacks an internal segment in the central coding region, compared to isoform 2.
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS45654.1
    UniProtKB/Swiss-Prot
    Q96H55
    UniProtKB/TrEMBL
    B4E218, B7Z1T7
    Related
    ENSP00000478437.1, ENST00000610930.4
    Conserved Domains (1) summary
    cl22853
    Location:49439
    Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36495636..36535338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525290.3XP_011523592.1  unconventional myosin-XIX isoform X5

    See identical proteins and their annotated locations for XP_011523592.1

    Conserved Domains (2) summary
    smart00242
    Location:36785
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49777
    MYSc_Myo19; class XIX myosin, motor domain
  2. XM_024450955.1XP_024306723.1  unconventional myosin-XIX isoform X1

    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  3. XM_017025158.2XP_016880647.1  unconventional myosin-XIX isoform X3

    Conserved Domains (1) summary
    cd14880
    Location:49792
    MYSc_Myo19; class XIX myosin, motor domain
  4. XM_017025159.2XP_016880648.1  unconventional myosin-XIX isoform X4

  5. XM_011525287.2XP_011523589.1  unconventional myosin-XIX isoform X2

    See identical proteins and their annotated locations for XP_011523589.1

    Conserved Domains (2) summary
    smart00242
    Location:36829
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49821
    MYSc_Myo19; class XIX myosin, motor domain
  6. XM_017025160.2XP_016880649.1  unconventional myosin-XIX isoform X6

  7. XM_011525286.2XP_011523588.1  unconventional myosin-XIX isoform X1

    See identical proteins and their annotated locations for XP_011523588.1

    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  8. XM_017025161.2XP_016880650.1  unconventional myosin-XIX isoform X7

    Conserved Domains (1) summary
    cl22853
    Location:45630
    Motor_domain; Myosin and Kinesin motor domain
  9. XM_017025157.1XP_016880646.1  unconventional myosin-XIX isoform X1

    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  10. XM_024450957.1XP_024306725.1  unconventional myosin-XIX isoform X7

    Conserved Domains (1) summary
    cl22853
    Location:45630
    Motor_domain; Myosin and Kinesin motor domain
  11. XM_024450956.1XP_024306724.1  unconventional myosin-XIX isoform X3

    Conserved Domains (1) summary
    cd14880
    Location:49792
    MYSc_Myo19; class XIX myosin, motor domain
  12. XM_024450954.1XP_024306722.1  unconventional myosin-XIX isoform X1

    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  13. XM_024450958.1XP_024306726.1  unconventional myosin-XIX isoform X8

    Conserved Domains (1) summary
    cl22853
    Location:33481
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_001752651.2 RNA Sequence

  2. XR_001752649.2 RNA Sequence

  3. XR_001752647.2 RNA Sequence

  4. XR_001752648.2 RNA Sequence

  5. XR_001752650.2 RNA Sequence

  6. XR_001752652.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    730540..769772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033579.1: Suppressed sequence

    Description
    NM_001033579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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