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DBF4B DBF4 zinc finger B [ Homo sapiens (human) ]

Gene ID: 80174, updated on 13-Oct-2022

Summary

Official Symbol
DBF4Bprovided by HGNC
Official Full Name
DBF4 zinc finger Bprovided by HGNC
Primary source
HGNC:HGNC:17883
See related
Ensembl:ENSG00000161692 MIM:611661; AllianceGenome:HGNC:17883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRF1; ASKL1; CHIFB; ZDBF1B
Summary
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Expression
Broad expression in testis (RPKM 5.4), brain (RPKM 1.1) and 22 other tissues See more
Orthologs
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Genomic context

See DBF4B in Genome Data Viewer
Location:
17q21.31; 17q21
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44708665..44752264)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45562625..45606211)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42786033..42829632)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371792 Neighboring gene uncharacterized LOC124904010 Neighboring gene coiled-coil domain containing 43 Neighboring gene RNA, 7SL, cytoplasmic 819, pseudogene Neighboring gene ribosomal protein L6 pseudogene 26 Neighboring gene uncharacterized LOC107985044 Neighboring gene ADAM metallopeptidase domain 11 Neighboring gene gap junction protein gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13087, MGC15009

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Dbf4-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein DBF4 homolog B
Names
ASK-like protein 1
DBF4 homolog B
Dbf4-related factor 1
activator of S-phase kinase-like protein 1
chiffon homolog B
zinc finger, DBF-type containing 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025104.4NP_079380.2  protein DBF4 homolog B isoform 2

    See identical proteins and their annotated locations for NP_079380.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW290902, BC016158
    Consensus CDS
    CCDS45706.2
    UniProtKB/Swiss-Prot
    Q8NFT6
    Related
    ENSP00000377178.2, ENST00000393547.6
    Conserved Domains (1) summary
    pfam07535
    Location:299340
    zf-DBF; DBF zinc finger
  2. NM_145663.3NP_663696.1  protein DBF4 homolog B isoform 1

    See identical proteins and their annotated locations for NP_663696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF448801, AW290902, BC016158
    Consensus CDS
    CCDS11485.1
    UniProtKB/Swiss-Prot
    Q8NFT6, Q9H912
    Related
    ENSP00000323663.3, ENST00000315005.8
    Conserved Domains (2) summary
    COG5067
    Location:18340
    DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
    pfam07535
    Location:299340
    zf-DBF; DBF zinc finger

RNA

  1. NR_036623.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005180, BC016158, BC033660, BM476186, DA475446
    Related
    ENST00000526924.5
  2. NR_148206.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple alternate internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005180, AC091152, AW290902
  3. NR_148207.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005180, AC091152, AW290902

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    44708665..44752264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436820.1XP_047292776.1  protein DBF4 homolog B isoform X15

  2. XM_017025150.3XP_016880639.1  protein DBF4 homolog B isoform X12

  3. XM_047436822.1XP_047292778.1  protein DBF4 homolog B isoform X18

  4. XM_047436817.1XP_047292773.1  protein DBF4 homolog B isoform X10

  5. XM_006722098.4XP_006722161.1  protein DBF4 homolog B isoform X2

    Conserved Domains (2) summary
    COG5067
    Location:18340
    DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
    pfam07535
    Location:299340
    zf-DBF; DBF zinc finger
  6. XM_047436814.1XP_047292770.1  protein DBF4 homolog B isoform X7

  7. XM_024450953.2XP_024306721.1  protein DBF4 homolog B isoform X4

    Conserved Domains (1) summary
    pfam07535
    Location:278319
    zf-DBF; DBF zinc finger
  8. XM_047436815.1XP_047292771.1  protein DBF4 homolog B isoform X8

  9. XM_047436810.1XP_047292766.1  protein DBF4 homolog B isoform X3

  10. XM_047436812.1XP_047292768.1  protein DBF4 homolog B isoform X5

  11. XM_047436811.1XP_047292767.1  protein DBF4 homolog B isoform X5

  12. XM_047436818.1XP_047292774.1  protein DBF4 homolog B isoform X11

  13. XM_047436821.1XP_047292777.1  protein DBF4 homolog B isoform X17

  14. XM_047436816.1XP_047292772.1  protein DBF4 homolog B isoform X9

  15. XM_047436819.1XP_047292775.1  protein DBF4 homolog B isoform X14

  16. XM_047436813.1XP_047292769.1  protein DBF4 homolog B isoform X6

  17. XM_047436809.1XP_047292765.1  protein DBF4 homolog B isoform X1

  18. XM_011525281.3XP_011523583.1  protein DBF4 homolog B isoform X13

    See identical proteins and their annotated locations for XP_011523583.1

    UniProtKB/Swiss-Prot
    Q8NFT6
    Conserved Domains (1) summary
    pfam07535
    Location:113154
    zf-DBF; DBF zinc finger
  19. XM_017025155.2XP_016880644.1  protein DBF4 homolog B isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45562625..45606211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)