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ABHD18 abhydrolase domain containing 18 [ Homo sapiens (human) ]

Gene ID: 80167, updated on 1-Jun-2020

Summary

Official Symbol
ABHD18provided by HGNC
Official Full Name
abhydrolase domain containing 18provided by HGNC
Primary source
HGNC:HGNC:26111
See related
Ensembl:ENSG00000164074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf29
Expression
Ubiquitous expression in heart (RPKM 3.9), duodenum (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See ABHD18 in Genome Data Viewer
Location:
4q28.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (127965261..128039927)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128886411..128957478)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 4 like Neighboring gene ribosomal protein L21 pseudogene 53 Neighboring gene RNA, U6 small nuclear 583, pseudogene Neighboring gene polo like kinase 4 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene La ribonucleoprotein 1B Neighboring gene ribosomal protein L15 pseudogene 8 Neighboring gene FOSL1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21106, MGC149227, MGC149228

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein ABHD18
Names
abhydrolase domain-containing protein 18
alpha/beta hydrolase domain-containing protein 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039717.2NP_001034806.1  protein ABHD18 isoform 6

    See identical proteins and their annotated locations for NP_001034806.1

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Related
    ENSP00000381937.1, ENST00000398965.5
    Conserved Domains (1) summary
    pfam09752
    Location:16414
    DUF2048; Abhydrolase domain containing 18
  2. NM_001319305.2NP_001306234.1  protein ABHD18 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant:This variant (1) lacks an alternate exon in the 5' region and uses a downstream start codon compared to variant 5. It encodes isoform 1 which has a shorter N-terminus compared to isoform 5 .
    Source sequence(s)
    AC099340, BC058847, BX119453, HY086029
    UniProtKB/TrEMBL
    B7WP89
    Related
    ENSP00000373447.5, ENST00000388795.9
    Conserved Domains (1) summary
    pfam09752
    Location:11375
    DUF2048; Uncharacterized conserved protein (DUF2048)
  3. NM_001319306.2NP_001306235.1  protein ABHD18 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' region and uses a downstream start codon compared to variant 5. It encodes isoform 2 which has a shorter N-terminus compared to isoform 5.
    Source sequence(s)
    AC099340, BC111400, BX119453
    Conserved Domains (1) summary
    cl21494
    Location:1330
    Abhydrolase; alpha/beta hydrolases
  4. NM_001319307.2NP_001306236.1  protein ABHD18 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences and uses a downstream start codon compared to variant 5. It encodes isoform 3 which has a shorter N-terminus compared to isoform 5.
    Source sequence(s)
    AC099340, BC058898, BX119453
    Conserved Domains (1) summary
    cl21494
    Location:1288
    Abhydrolase; alpha/beta hydrolases
  5. NM_001358451.2NP_001345380.1  protein ABHD18 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 5. It encodes isoform 4 which is shorter compared to isoform 5.
    Source sequence(s)
    AC099340, BX119453
    Consensus CDS
    CCDS87261.1
    Related
    ENSP00000496010.1, ENST00000645843.1
    Conserved Domains (1) summary
    pfam09752
    Location:16457
    DUF2048; Abhydrolase domain containing 18
  6. NM_001358454.2NP_001345383.1  protein ABHD18 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC099340, BX119453
    Conserved Domains (1) summary
    pfam09752
    Location:16472
    DUF2048; Abhydrolase domain containing 18
  7. NM_001366037.2NP_001352966.1  protein ABHD18 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1254
    Abhydrolase; alpha/beta hydrolases
  8. NM_001366038.2NP_001352967.1  protein ABHD18 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:109409
    Abhydrolase; alpha/beta hydrolases
  9. NM_001366039.2NP_001352968.1  protein ABHD18 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    pfam09752
    Location:16423
    DUF2048; Abhydrolase domain containing 18
  10. NM_001366040.2NP_001352969.1  protein ABHD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1288
    Abhydrolase; alpha/beta hydrolases
  11. NM_001366041.2NP_001352970.1  protein ABHD18 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1296
    Abhydrolase; alpha/beta hydrolases
  12. NM_001366042.2NP_001352971.1  protein ABHD18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1288
    Abhydrolase; alpha/beta hydrolases
  13. NM_001366043.1NP_001352972.1  protein ABHD18 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    pfam09752
    Location:16448
    DUF2048; Abhydrolase domain containing 18
  14. NM_001366044.1NP_001352973.1  protein ABHD18 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1321
    Abhydrolase; alpha/beta hydrolases
  15. NM_001366045.1NP_001352974.1  protein ABHD18 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1321
    Abhydrolase; alpha/beta hydrolases
  16. NM_001366046.1NP_001352975.1  protein ABHD18 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1279
    Abhydrolase; alpha/beta hydrolases
  17. NM_001366047.1NP_001352976.1  protein ABHD18 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Related
    ENSP00000480015.1, ENST00000611882.1
    Conserved Domains (1) summary
    cl21494
    Location:1321
    Abhydrolase; alpha/beta hydrolases
  18. NM_001366048.1NP_001352977.1  protein ABHD18 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:11332
    Abhydrolase; alpha/beta hydrolases
  19. NM_025097.2NP_079373.2  protein ABHD18 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC099340
    Conserved Domains (1) summary
    cl21494
    Location:1245
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    127965261..128039927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532274.3XP_011530576.1  protein ABHD18 isoform X3

    Conserved Domains (1) summary
    pfam09752
    Location:16438
    DUF2048; Uncharacterized conserved protein (DUF2048)
  2. XM_011532276.2XP_011530578.1  protein ABHD18 isoform X4

    Conserved Domains (1) summary
    pfam09752
    Location:16429
    DUF2048; Uncharacterized conserved protein (DUF2048)
  3. XM_011532278.3XP_011530580.1  protein ABHD18 isoform X6

    Conserved Domains (1) summary
    cl21494
    Location:11341
    Abhydrolase; alpha/beta hydrolases
  4. XM_006714320.3XP_006714383.1  protein ABHD18 isoform X1

    See identical proteins and their annotated locations for XP_006714383.1

    Conserved Domains (1) summary
    pfam09752
    Location:16472
    DUF2048; Abhydrolase domain containing 18
  5. XM_024454226.1XP_024309994.1  protein ABHD18 isoform X1

    Conserved Domains (1) summary
    pfam09752
    Location:16472
    DUF2048; Abhydrolase domain containing 18
  6. XM_024454227.1XP_024309995.1  protein ABHD18 isoform X2

    Conserved Domains (1) summary
    pfam09752
    Location:16457
    DUF2048; Abhydrolase domain containing 18
  7. XM_006714322.3XP_006714385.1  protein ABHD18 isoform X7

    See identical proteins and their annotated locations for XP_006714385.1

    Conserved Domains (1) summary
    cl21494
    Location:1330
    Abhydrolase; alpha/beta hydrolases
  8. XM_011532279.2XP_011530581.1  protein ABHD18 isoform X9

    See identical proteins and their annotated locations for XP_011530581.1

    Conserved Domains (1) summary
    cl21494
    Location:1288
    Abhydrolase; alpha/beta hydrolases
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