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PGGHG protein-glucosylgalactosylhydroxylysine glucosidase [ Homo sapiens (human) ]

Gene ID: 80162, updated on 23-Nov-2021

Summary

Official Symbol
PGGHGprovided by HGNC
Official Full Name
protein-glucosylgalactosylhydroxylysine glucosidaseprovided by HGNC
Primary source
HGNC:HGNC:26210
See related
Ensembl:ENSG00000142102 MIM:617032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATHL1
Expression
Broad expression in lymph node (RPKM 33.9), pancreas (RPKM 29.5) and 24 other tissues See more
Orthologs
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Genomic context

See PGGHG in Genome Data Viewer
Location:
11p15.5
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (287760..296107)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (289126..296107)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 8B, pseudogene Neighboring gene NLR family pyrin domain containing 6 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22635, MGC129858, MGC129859

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein-glucosylgalactosylhydroxylysine glucosidase
Names
ATH1, acid trehalase-like 1
acid trehalase-like protein 1
testicular tissue protein Li 25
NP_079368.3
XP_011518685.1
XP_011518686.1
XP_011518687.1
XP_011518688.1
XP_011518689.1
XP_016873844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025092.5NP_079368.3  protein-glucosylgalactosylhydroxylysine glucosidase

    See identical proteins and their annotated locations for NP_079368.3

    Status: VALIDATED

    Source sequence(s)
    AC136475, AI217945, AI919161, AL832932, BC109257, BM842384, BP262327, CN298034
    Consensus CDS
    CCDS31322.2
    UniProtKB/Swiss-Prot
    Q32M88
    UniProtKB/TrEMBL
    A0A024R1Z9
    Related
    ENSP00000387185.2, ENST00000409548.7
    Conserved Domains (3) summary
    COG1554
    Location:23659
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292608
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    287760..296107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520383.2XP_011518685.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

    See identical proteins and their annotated locations for XP_011518685.1

    UniProtKB/Swiss-Prot
    Q32M88
    UniProtKB/TrEMBL
    A0A024R1Z9
    Conserved Domains (3) summary
    COG1554
    Location:23659
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292608
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)
  2. XM_011520385.3XP_011518687.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X3

    Conserved Domains (3) summary
    COG1554
    Location:23491
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292491
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)
  3. XM_011520386.2XP_011518688.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X4

    Conserved Domains (3) summary
    COG1554
    Location:23424
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292424
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)
  4. XM_011520387.2XP_011518689.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X5

    Conserved Domains (3) summary
    COG1554
    Location:23423
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292423
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)
  5. XM_011520384.2XP_011518686.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2

    Conserved Domains (3) summary
    COG1554
    Location:23641
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292604
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)
  6. XM_017018355.1XP_016873844.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

    UniProtKB/Swiss-Prot
    Q32M88
    UniProtKB/TrEMBL
    A0A024R1Z9
    Conserved Domains (3) summary
    COG1554
    Location:23659
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:292608
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain
    pfam10222
    Location:16297
    DUF2152; Uncharacterized conserved protein (DUF2152)

RNA

  1. XR_428856.3 RNA Sequence

  2. XR_930912.2 RNA Sequence

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