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NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 80155, updated on 17-Jun-2019

Summary

Official Symbol
NAA15provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:30782
See related
Ensembl:ENSG00000164134 MIM:608000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100
Summary
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See NAA15 in Genome Data Viewer
Location:
4q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (139301499..139391384)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140222621..140311935)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1074, pseudogene Neighboring gene mitochondria localized glutamic acid rich protein Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene RNA, U6 small nuclear 1214, pseudogene Neighboring gene uncharacterized LOC105377449 Neighboring gene glucose-fructose oxidoreductase domain containing 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MENTAL RETARDATION, AUTOSOMAL DOMINANT 50
MedGen: C4540470 OMIM: 617787 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2019-02-27)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2019-02-27)

ClinGen Genome Curation PagePubMed

Pathways from BioSystems

  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
contributes_to acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NatA complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Names
N-terminal acetyltransferase
NMDA receptor regulated 1
NMDA receptor-regulated protein 1
gastric cancer antigen Ga19
protein tubedown-1
transcriptional coactivator tubedown-100
tubedown-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053037.1 RefSeqGene

    Range
    5001..94315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057175.5NP_476516.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit

    See identical proteins and their annotated locations for NP_476516.1

    Status: REVIEWED

    Source sequence(s)
    AC097376, AY039242, BX499137
    Consensus CDS
    CCDS43270.1
    UniProtKB/Swiss-Prot
    Q9BXJ9
    UniProtKB/TrEMBL
    B2RBE5
    Related
    ENSP00000296543.4, ENST00000296543.10
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1
    cl26002
    Location:90271
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    139301499..139391384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263236.3XP_005263293.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_005263293.1

    UniProtKB/TrEMBL
    A0A0B4J1W3
    Related
    ENSP00000381920.1, ENST00000398947.1
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82145
    TPR_11; TPR repeat
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