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NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 80155, updated on 25-Nov-2021

Summary

Official Symbol
NAA15provided by HGNC
Official Full Name
N-alpha-acetyltransferase 15, NatA auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:30782
See related
Ensembl:ENSG00000164134 MIM:608000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100
Summary
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

See NAA15 in Genome Data Viewer
Location:
4q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (139301499..139391384)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140222659..140312538)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1074, pseudogene Neighboring gene mitochondria localized glutamic acid rich protein Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene RNA, U6 small nuclear 1214, pseudogene Neighboring gene uncharacterized LOC105377449 Neighboring gene glucose-fructose oxidoreductase domain containing 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intellectual disability, autosomal dominant 50
MedGen: C4540470 OMIM: 617787 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-04-13)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-04-13)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
contributes_to acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NatA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NatA complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Names
N-terminal acetyltransferase
NMDA receptor regulated 1
NMDA receptor-regulated protein 1
gastric cancer antigen Ga19
protein tubedown-1
transcriptional coactivator tubedown-100
tubedown-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053037.1 RefSeqGene

    Range
    5039..94918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057175.5NP_476516.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit

    See identical proteins and their annotated locations for NP_476516.1

    Status: REVIEWED

    Source sequence(s)
    AC097376, AY039242, BX499137
    Consensus CDS
    CCDS43270.1
    UniProtKB/Swiss-Prot
    Q9BXJ9
    UniProtKB/TrEMBL
    B2RBE5
    Related
    ENSP00000296543.4, ENST00000296543.10
    Conserved Domains (3) summary
    TIGR02917
    Location:90271
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    139301499..139391384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263236.3XP_005263293.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_005263293.1

    UniProtKB/TrEMBL
    A0A0B4J1W3
    Related
    ENSP00000381920.1, ENST00000398947.1
    Conserved Domains (3) summary
    PRK09782
    Location:375438
    PRK09782; bacteriophage N4 receptor, outer membrane subunit; Provisional
    TIGR02917
    Location:90271
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
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