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CENPT centromere protein T [ Homo sapiens (human) ]

Gene ID: 80152, updated on 2-Oct-2018

Summary

Official Symbol
CENPTprovided by HGNC
Official Full Name
centromere protein Tprovided by HGNC
Primary source
HGNC:HGNC:25787
See related
Ensembl:ENSG00000102901 MIM:611510; Vega:OTTHUMG00000173071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-T; C16orf56
Summary
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in skin (RPKM 26.3), testis (RPKM 20.1) and 25 other tissues See more
Orthologs

Genomic context

See CENPT in Genome Data Viewer
Location:
16q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (67828157..67847458, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67862060..67881361, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene RAN binding protein 10 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
    Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
  • Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystem (from REACTOME)
    Deposition of new CENPA-containing nucleosomes at the centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Nucleosome assembly, organism-specific biosystem (from REACTOME)
    Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13111, FLJ43376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
centromere protein T
Names
interphase centromere complex protein 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025082.3NP_079358.3  centromere protein T

    See identical proteins and their annotated locations for NP_079358.3

    Status: VALIDATED

    Source sequence(s)
    AK056097, AK225399, CD242240
    Consensus CDS
    CCDS42182.1
    UniProtKB/Swiss-Prot
    Q96BT3
    UniProtKB/TrEMBL
    B3KPB2
    Related
    ENSP00000457810.1, OTTHUMP00000250061, ENST00000562787.5, OTTHUMT00000422020
    Conserved Domains (2) summary
    pfam15511
    Location:450553
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1413
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    67828157..67847458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450456.1XP_024306224.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  2. XM_024450457.1XP_024306225.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  3. XM_024450455.1XP_024306223.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  4. XM_024450458.1XP_024306226.1  centromere protein T isoform X2

  5. XM_017023715.1XP_016879204.1  centromere protein T isoform X2

  6. XM_011523345.1XP_011521647.1  centromere protein T isoform X3

    Conserved Domains (2) summary
    pfam15511
    Location:203306
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:4166
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  7. XM_017023717.1XP_016879206.1  centromere protein T isoform X3

    Conserved Domains (2) summary
    pfam15511
    Location:203306
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:4166
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
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