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CENPT centromere protein T [ Homo sapiens (human) ]

Gene ID: 80152, updated on 16-Oct-2021

Summary

Official Symbol
CENPTprovided by HGNC
Official Full Name
centromere protein Tprovided by HGNC
Primary source
HGNC:HGNC:25787
See related
Ensembl:ENSG00000102901 MIM:611510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSMGA; CENP-T; C16orf56
Summary
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in skin (RPKM 26.3), testis (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

See CENPT in Genome Data Viewer
Location:
16q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67828157..67847693, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67862060..67881596, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAN binding protein 10 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Short stature and microcephaly with genital anomalies
MedGen: C5231467 OMIM: 618702 GeneReviews: Not available
not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13111, FLJ43376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centromere protein T
Names
interphase centromere complex protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025082.4NP_079358.3  centromere protein T

    See identical proteins and their annotated locations for NP_079358.3

    Status: VALIDATED

    Source sequence(s)
    AC040162, AK056097, AK225399, CD242240
    Consensus CDS
    CCDS42182.1
    UniProtKB/Swiss-Prot
    Q96BT3
    UniProtKB/TrEMBL
    B3KPB2
    Related
    ENSP00000457810.1, ENST00000562787.6
    Conserved Domains (2) summary
    pfam16171
    Location:1415
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
    cl23735
    Location:450551
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67828157..67847693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450456.1XP_024306224.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  2. XM_024450457.1XP_024306225.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  3. XM_024450455.1XP_024306223.1  centromere protein T isoform X1

    Conserved Domains (2) summary
    pfam15511
    Location:347450
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:1310
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  4. XM_024450458.1XP_024306226.1  centromere protein T isoform X2

    Related
    ENST00000565157.5
    Conserved Domains (2) summary
    pfam15511
    Location:208311
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:123171
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  5. XM_017023715.1XP_016879204.1  centromere protein T isoform X2

    Conserved Domains (2) summary
    pfam15511
    Location:208311
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:123171
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  6. XM_011523345.1XP_011521647.1  centromere protein T isoform X3

    Conserved Domains (2) summary
    pfam15511
    Location:203306
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:4166
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
  7. XM_017023717.1XP_016879206.1  centromere protein T isoform X3

    Conserved Domains (2) summary
    pfam15511
    Location:203306
    CENP-T_C; Centromere kinetochore component CENP-T histone fold
    pfam16171
    Location:4166
    CENP-T_N; Centromere kinetochore component CENP-T N-terminus
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