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ASRGL1 asparaginase like 1 [ Homo sapiens (human) ]

Gene ID: 80150, updated on 15-Jul-2018
Official Symbol
ASRGL1provided by HGNC
Official Full Name
asparaginase like 1provided by HGNC
Primary source
HGNC:HGNC:16448
See related
Ensembl:ENSG00000162174 MIM:609212; Vega:OTTHUMG00000167513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; ALP1; CRASH
Expression
Biased expression in testis (RPKM 38.7), kidney (RPKM 13.5) and 10 other tissues See more
Orthologs
See ASRGL1 in Genome Data Viewer
Location:
11q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (62337302..62401401)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62104774..62160887)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1D member 4 Neighboring gene nucleophosmin 1 pseudogene 35 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC107984335 Neighboring gene uncharacterized LOC102723765 Neighboring gene secretoglobin family 1A member 1 Neighboring gene AHNAK nucleoprotein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of asparaginase like 1 (ASRGL1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystem (from REACTOME)
    Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystemThe catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002).
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Phenylalanine and tyrosine catabolism, organism-specific biosystem (from REACTOME)
    Phenylalanine and tyrosine catabolism, organism-specific biosystemThe first reaction in this pathway converts phenylalanine to tyrosine, coupled to the conversion of tetrahydrobiopterin to 4a-hydroxytetrahydrobiopterin, catalyzed by phenylalanine hydroxylase. (Defi...
  • asparagine degradation, organism-specific biosystem (from BIOCYC)
    asparagine degradation, organism-specific biosystemGeneral Background : ASN "Asparagine" is the amide of : L-ASPARTATE and is not an essential amino acid. It is synthesized in humans from : OXALACETIC_ACID in : ASPARAGINE-BIOSYNTHESIS. The amide gro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-aspartyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-aspartyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-aspartyl-peptidase activity TAS
Traceable Author Statement
more info
 
hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 
asparagine catabolic process via L-aspartate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine catabolic process via L-aspartate IDA
Inferred from Direct Assay
more info
PubMed 
asparagine catabolic process via L-aspartate ISS
Inferred from Sequence or Structural Similarity
more info
 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
Preferred Names
isoaspartyl peptidase/L-asparaginase
Names
L-asparaginase
L-asparagine amidohydrolase
asparaginase-like 1 protein
asparaginase-like protein 1
beta-aspartyl-peptidase
isoaspartyl dipeptidase
testis secretory sperm-binding protein Li 242mP
NP_001077395.1
NP_079356.3
XP_005274362.1
XP_005274363.1
XP_011543567.1
XP_011543568.1
XP_016873843.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083926.1NP_001077395.1  isoaspartyl peptidase/L-asparaginase

    See identical proteins and their annotated locations for NP_001077395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003064, BC093070, BP308677, DA159051, DT220454
    Consensus CDS
    CCDS8019.1
    UniProtKB/Swiss-Prot
    Q7L266
    UniProtKB/TrEMBL
    A0A024R573
    Related
    ENSP00000400057.2, OTTHUMP00000236068, ENST00000415229.6, OTTHUMT00000394865
    Conserved Domains (2) summary
    PRK10226
    Location:1290
    PRK10226; isoaspartyl peptidase; Provisional
    cd04702
    Location:2291
    ASRGL1_like; Metazoan L-Asparaginase type 2
  2. NM_025080.3NP_079356.3  isoaspartyl peptidase/L-asparaginase

    See identical proteins and their annotated locations for NP_079356.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003064, BC021295, BP308677, DT220454
    Consensus CDS
    CCDS8019.1
    UniProtKB/Swiss-Prot
    Q7L266
    UniProtKB/TrEMBL
    A0A024R573
    Related
    ENSP00000301776.5, OTTHUMP00000236070, ENST00000301776.9, OTTHUMT00000394867
    Conserved Domains (2) summary
    PRK10226
    Location:1290
    PRK10226; isoaspartyl peptidase; Provisional
    cd04702
    Location:2291
    ASRGL1_like; Metazoan L-Asparaginase type 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    62337302..62401401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545265.3XP_011543567.1  isoaspartyl peptidase/L-asparaginase isoform X1

    Conserved Domains (1) summary
    cd04702
    Location:2203
    ASRGL1_like; Metazoan L-Asparaginase type 2
  2. XM_011545266.3XP_011543568.1  isoaspartyl peptidase/L-asparaginase isoform X2

    Conserved Domains (1) summary
    cl00635
    Location:2183
    Ntn_Asparaginase_2_like; L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily
  3. XM_017018354.2XP_016873843.1  isoaspartyl peptidase/L-asparaginase isoform X4

    Related
    ENSP00000478649.1, OTTHUMP00000275638, ENST00000534571.5
  4. XM_005274305.4XP_005274362.1  isoaspartyl peptidase/L-asparaginase isoform X3

    See identical proteins and their annotated locations for XP_005274362.1

    UniProtKB/Swiss-Prot
    Q7L266
    Conserved Domains (1) summary
    cd04702
    Location:1163
    ASRGL1_like; Metazoan L-Asparaginase type 2
  5. XM_005274306.2XP_005274363.1  isoaspartyl peptidase/L-asparaginase isoform X3

    See identical proteins and their annotated locations for XP_005274363.1

    UniProtKB/Swiss-Prot
    Q7L266
    Conserved Domains (1) summary
    cd04702
    Location:1163
    ASRGL1_like; Metazoan L-Asparaginase type 2

RNA

  1. XR_002957199.1 RNA Sequence

  2. XR_002957198.1 RNA Sequence

  3. XR_001747982.2 RNA Sequence

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