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ASRGL1 asparaginase and isoaspartyl peptidase 1 [ Homo sapiens (human) ]

Gene ID: 80150, updated on 8-Jul-2021

Summary

Official Symbol
ASRGL1provided by HGNC
Official Full Name
asparaginase and isoaspartyl peptidase 1provided by HGNC
Primary source
HGNC:HGNC:16448
See related
Ensembl:ENSG00000162174 MIM:609212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; ALP1; CRASH
Expression
Biased expression in testis (RPKM 38.7), kidney (RPKM 13.5) and 10 other tissues See more
Orthologs
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Genomic context

See ASRGL1 in Genome Data Viewer
Location:
11q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62337430..62401401)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62104920..62160884)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1D member 4 Neighboring gene nucleophosmin 1 pseudogene 35 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC107984335 Neighboring gene uncharacterized LOC102723765 Neighboring gene secretoglobin family 1A member 1 Neighboring gene AHNAK nucleoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of asparaginase like 1 (ASRGL1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables asparaginase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables beta-aspartyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-aspartyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in asparagine catabolic process via L-aspartate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in asparagine catabolic process via L-aspartate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in asparagine catabolic process via L-aspartate ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
located_in photoreceptor inner segment ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
isoaspartyl peptidase/L-asparaginase
Names
L-asparaginase
L-asparagine amidohydrolase
asparaginase like 1
asparaginase-like 1 protein
asparaginase-like protein 1
beta-aspartyl-peptidase
isoaspartyl dipeptidase
testis secretory sperm-binding protein Li 242mP
NP_001077395.1
NP_079356.3
XP_005274362.1
XP_005274363.1
XP_011543567.1
XP_011543568.1
XP_016873843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083926.2NP_001077395.1  isoaspartyl peptidase/L-asparaginase

    See identical proteins and their annotated locations for NP_001077395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003064, BC093070, DA159051, DT220454
    Consensus CDS
    CCDS8019.1
    UniProtKB/Swiss-Prot
    Q7L266
    UniProtKB/TrEMBL
    A0A024R573
    Related
    ENSP00000400057.2, ENST00000415229.6
    Conserved Domains (2) summary
    PRK10226
    Location:1290
    PRK10226; isoaspartyl peptidase; Provisional
    cd04702
    Location:2291
    ASRGL1_like; Metazoan L-Asparaginase type 2
  2. NM_025080.4NP_079356.3  isoaspartyl peptidase/L-asparaginase

    See identical proteins and their annotated locations for NP_079356.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003064, BC021295, BP308677, DT220454
    Consensus CDS
    CCDS8019.1
    UniProtKB/Swiss-Prot
    Q7L266
    UniProtKB/TrEMBL
    A0A024R573
    Related
    ENSP00000301776.5, ENST00000301776.9
    Conserved Domains (2) summary
    PRK10226
    Location:1290
    PRK10226; isoaspartyl peptidase; Provisional
    cd04702
    Location:2291
    ASRGL1_like; Metazoan L-Asparaginase type 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62337430..62401401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545265.3XP_011543567.1  isoaspartyl peptidase/L-asparaginase isoform X1

    Conserved Domains (1) summary
    cd04702
    Location:2203
    ASRGL1_like; Metazoan L-Asparaginase type 2
  2. XM_011545266.3XP_011543568.1  isoaspartyl peptidase/L-asparaginase isoform X2

    Conserved Domains (1) summary
    cl00635
    Location:2183
    Ntn_Asparaginase_2_like; L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily
  3. XM_017018354.2XP_016873843.1  isoaspartyl peptidase/L-asparaginase isoform X4

    Related
    ENSP00000478649.1, ENST00000534571.5
  4. XM_005274305.4XP_005274362.1  isoaspartyl peptidase/L-asparaginase isoform X3

    See identical proteins and their annotated locations for XP_005274362.1

    UniProtKB/Swiss-Prot
    Q7L266
    Conserved Domains (1) summary
    cd04702
    Location:1163
    ASRGL1_like; Metazoan L-Asparaginase type 2
  5. XM_005274306.2XP_005274363.1  isoaspartyl peptidase/L-asparaginase isoform X3

    See identical proteins and their annotated locations for XP_005274363.1

    UniProtKB/Swiss-Prot
    Q7L266
    Conserved Domains (1) summary
    cd04702
    Location:1163
    ASRGL1_like; Metazoan L-Asparaginase type 2

RNA

  1. XR_002957199.1 RNA Sequence

  2. XR_002957198.1 RNA Sequence

  3. XR_001747982.2 RNA Sequence

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