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ZC3H12A zinc finger CCCH-type containing 12A [ Homo sapiens (human) ]

Gene ID: 80149, updated on 21-Oct-2019

Summary

Official Symbol
ZC3H12Aprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 12Aprovided by HGNC
Primary source
HGNC:HGNC:26259
See related
Ensembl:ENSG00000163874 MIM:610562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Reg1; MCPIP; MCPIP1; MCPIP-1; dJ423B22.1
Summary
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]
Expression
Broad expression in bone marrow (RPKM 42.1), urinary bladder (RPKM 18.8) and 17 other tissues See more
Orthologs

Genomic context

See ZC3H12A in Genome Data Viewer
Location:
1p34.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (37474518..37484377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (37940119..37949978)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984942 Neighboring gene long intergenic non-protein coding RNA 1137 Neighboring gene Sharpr-MPRA regulatory region 4732 Neighboring gene microRNA 6732 Neighboring gene MYST/Esa1 associated factor 6 Neighboring gene microRNA 5581 Neighboring gene uncharacterized LOC105378649 Neighboring gene Smad nuclear interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA stem-loop binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
endoribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exoribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to thiol-dependent ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
3'-UTR-mediated mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA phosphodiester bond hydrolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to chemokine IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to ionomycin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to sodium arsenite ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response-activating signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation by host of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage activation IC
Inferred by Curator
more info
PubMed 
negative regulation of muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of miRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endoribonuclease ZC3H12A
Names
MCP-1 treatment-induced protein
MCP-induced protein 1
bifunctional endoribonuclease and deubiquitinase ZC3H12A
monocyte chemotactic protein-induced protein 1
regnase-1
ribonuclease ZC3H12A
zinc finger CCCH domain-containing protein 12A
NP_001310479.1
NP_001310480.1
NP_079355.2
XP_011540500.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323550.2NP_001310479.1  endoribonuclease ZC3H12A isoform a

    Status: VALIDATED

    Source sequence(s)
    AL034379, AL449284
    Consensus CDS
    CCDS417.1
    UniProtKB/Swiss-Prot
    Q5D1E8
    Conserved Domains (1) summary
    pfam11977
    Location:134290
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  2. NM_001323551.2NP_001310480.1  endoribonuclease ZC3H12A isoform b

    Status: VALIDATED

    Source sequence(s)
    AL034379, AL449284
  3. NM_025079.3NP_079355.2  endoribonuclease ZC3H12A isoform a

    See identical proteins and their annotated locations for NP_079355.2

    Status: VALIDATED

    Source sequence(s)
    BC005001, CR995909, DA601465
    Consensus CDS
    CCDS417.1
    UniProtKB/Swiss-Prot
    Q5D1E8
    Related
    ENSP00000362179.5, ENST00000373087.7
    Conserved Domains (1) summary
    pfam11977
    Location:134290
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    37474518..37484377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542198.2XP_011540500.1  endoribonuclease ZC3H12A isoform X1

    Conserved Domains (1) summary
    pfam11977
    Location:134274
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RNA

  1. XR_001737436.2 RNA Sequence

    Related
    ENST00000640233.1
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