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THOC7 THO complex 7 [ Homo sapiens (human) ]

Gene ID: 80145, updated on 8-Jul-2021

Summary

Official Symbol
THOC7provided by HGNC
Official Full Name
THO complex 7provided by HGNC
Primary source
HGNC:HGNC:29874
See related
Ensembl:ENSG00000163634 MIM:611965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
fSAP24; hTREX30; NIF3L1BP1
Expression
Ubiquitous expression in adrenal (RPKM 20.0), colon (RPKM 19.8) and 25 other tissues See more
Orthologs
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Genomic context

See THOC7 in Genome Data Viewer
Location:
3p14.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (63833870..63864478, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (63819546..63849481, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377119 Neighboring gene cadherin-related family member 3-like Neighboring gene chromosome 3 open reading frame 49 Neighboring gene THOC7 antisense RNA 1 Neighboring gene ataxin 7 Neighboring gene ataxin 7 repeat instability region Neighboring gene SCA7/ATXN7 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 7 homolog
Names
NIF3L1-binding protein 1
Ngg1 interacting factor 3 like 1 binding protein 1
THO complex 7 homolog
functional spliceosome-associated protein 24
ngg1-interacting factor 3-like protein 1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285387.3NP_001272316.1  THO complex subunit 7 homolog isoform 2

    See identical proteins and their annotated locations for NP_001272316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant (1). The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variant 2 and 3 encode the same isoform.
    Source sequence(s)
    AF104914, AK225110
    Consensus CDS
    CCDS74957.1
    UniProtKB/TrEMBL
    A0A024R341
    Related
    ENSP00000418518.2, ENST00000469584.5
    Conserved Domains (1) summary
    pfam05615
    Location:187
    THOC7; Tho complex subunit 7
  2. NM_001285404.2NP_001272333.1  THO complex subunit 7 homolog isoform 2

    See identical proteins and their annotated locations for NP_001272333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant (1). The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variant 2 and 3 encode the same isoform.
    Source sequence(s)
    AC104162, AF104914, BC065012, BI914906
    Consensus CDS
    CCDS74957.1
    UniProtKB/Swiss-Prot
    Q6I9Y2
    UniProtKB/TrEMBL
    A0A024R341
    Conserved Domains (1) summary
    pfam05615
    Location:187
    THOC7; Tho complex subunit 7
  3. NM_025075.4NP_079351.2  THO complex subunit 7 homolog isoform 1

    See identical proteins and their annotated locations for NP_079351.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK225110
    Consensus CDS
    CCDS2900.1
    UniProtKB/Swiss-Prot
    Q6I9Y2
    UniProtKB/TrEMBL
    A0A024R332
    Related
    ENSP00000295899.5, ENST00000295899.10
    Conserved Domains (1) summary
    pfam05615
    Location:7139
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    63833870..63864478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713339.3XP_006713402.1  THO complex subunit 7 homolog isoform X1

    See identical proteins and their annotated locations for XP_006713402.1

    UniProtKB/TrEMBL
    A0A024R341
    Conserved Domains (1) summary
    pfam05615
    Location:187
    THOC7; Tho complex subunit 7
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