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PTGES2 prostaglandin E synthase 2 [ Homo sapiens (human) ]

Gene ID: 80142, updated on 7-Jun-2020

Summary

Official Symbol
PTGES2provided by HGNC
Official Full Name
prostaglandin E synthase 2provided by HGNC
Primary source
HGNC:HGNC:17822
See related
Ensembl:ENSG00000148334 MIM:608152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBF1; GBF-1; PGES2; C9orf15; mPGES-2
Summary
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in heart (RPKM 13.3), kidney (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See PTGES2 in Genome Data Viewer
Location:
9q34.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128120693..128128462, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130882972..130890741, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 25 Neighboring gene SLC25A25 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4689 Neighboring gene PTGES2 antisense RNA 1 (head to head) Neighboring gene CRISPRi-validated cis-regulatory element chr9.2942

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14038, MGC11289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
glutathione binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin-E synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prostaglandin E synthase 2
Names
GATE-binding factor 1
gamma-interferon-activated transcriptional element-binding factor 1
mPGE synthase-2
membrane-associated prostaglandin E synthase 2
microsomal prostaglandin E synthase-2
prostaglandin-H(2) E-isomerase
NP_001243264.1
NP_079348.1
NP_945176.1
XP_005252296.1
XP_011517352.1
XP_011517353.1
XP_024303456.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012488.1 RefSeqGene

    Range
    5467..12503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256335.1NP_001243264.1  prostaglandin E synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_001243264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode isoform 2.
    Source sequence(s)
    AL590708, BC011613, BG481657, BX493085
    UniProtKB/Swiss-Prot
    Q9H7Z7
    UniProtKB/TrEMBL
    A6NHH0
    Related
    ENSP00000482913.1, ENST00000617202.4
    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
  2. NM_025072.7NP_079348.1  prostaglandin E synthase 2 isoform 1

    See identical proteins and their annotated locations for NP_079348.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590708, BC011613
    Consensus CDS
    CCDS6891.1
    UniProtKB/Swiss-Prot
    Q9H7Z7
    UniProtKB/TrEMBL
    B3KPZ2
    Related
    ENSP00000345341.6, ENST00000338961.11
    Conserved Domains (2) summary
    cd03197
    Location:224370
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    cd03040
    Location:101177
    GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...
  3. NM_198938.2NP_945176.1  prostaglandin E synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_945176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode isoform 2.
    Source sequence(s)
    AK057049, AK301618, AL590708, BC011613
    UniProtKB/Swiss-Prot
    Q9H7Z7
    UniProtKB/TrEMBL
    A6NHH0, B3KPZ2, B4DWP1
    Related
    ENSP00000277462.5, ENST00000277462.9
    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128120693..128128462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519050.1XP_011517352.1  prostaglandin E synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_011517352.1

    UniProtKB/TrEMBL
    A6NHH0
    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
  2. XM_024447688.1XP_024303456.1  prostaglandin E synthase 2 isoform X1

    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
  3. XM_011519051.3XP_011517353.1  prostaglandin E synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_011517353.1

    UniProtKB/TrEMBL
    A6NHH0
    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
  4. XM_005252239.2XP_005252296.1  prostaglandin E synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_005252296.1

    UniProtKB/TrEMBL
    A6NHH0
    Conserved Domains (1) summary
    cd03197
    Location:33179
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

RNA

  1. XR_001746383.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198939.1: Suppressed sequence

    Description
    NM_198939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_198940.1: Suppressed sequence

    Description
    NM_198940.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  3. NR_027812.1: Suppressed sequence

    Description
    NR_027812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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