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CCDC33 coiled-coil domain containing 33 [ Homo sapiens (human) ]

Gene ID: 80125, updated on 22-Aug-2020

Summary

Official Symbol
CCDC33provided by HGNC
Official Full Name
coiled-coil domain containing 33provided by HGNC
Primary source
HGNC:HGNC:26552
See related
Ensembl:ENSG00000140481 MIM:618525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT61; HP11097
Expression
Restricted expression toward testis (RPKM 3.1) See more
Orthologs

Genomic context

See CCDC33 in Genome Data Viewer
Location:
15q24.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74216640..74336472)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74528630..74628813)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily containing leucine rich repeat Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene uncharacterized LOC105370893 Neighboring gene cytochrome P450 family 11 subfamily A member 1 Neighboring gene CYP11A1 promoter region Neighboring gene peptidylprolyl isomerase A pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23168, FLJ32855, MGC34145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 33
Names
cancer/testis antigen 61
hypothetical protein HP11097

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054754.1 RefSeqGene

    Range
    38622..138437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001287181.2NP_001274110.1  coiled-coil domain-containing protein 33 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate exon structure in both its 5' and 3' regions, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AK026821, AK290709, BC025689
    Consensus CDS
    CCDS73753.1
    UniProtKB/Swiss-Prot
    Q8N5R6
    Related
    ENSP00000452817.1, ENST00000558821.5
    Conserved Domains (1) summary
    TIGR02169
    Location:24167
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. NM_025055.5NP_079331.3  coiled-coil domain-containing protein 33 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC023300, AI223423, AK057417, BC031684, DB049940
    Consensus CDS
    CCDS42058.1
    UniProtKB/Swiss-Prot
    Q8N5R6
    Related
    ENSP00000381795.3, ENST00000398814.8
    Conserved Domains (1) summary
    cd00030
    Location:37132
    C2; C2 domain
  3. NM_182791.4NP_877592.2  coiled-coil domain-containing protein 33 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exon structure in both its 5' and 3' regions, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AK026821, AK290709, BC025689
    Consensus CDS
    CCDS42059.1
    UniProtKB/Swiss-Prot
    Q8N5R6
    Related
    ENSP00000268082.4, ENST00000268082.4
    Conserved Domains (1) summary
    TIGR02169
    Location:24167
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74216640..74336472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022633.1XP_016878122.1  coiled-coil domain-containing protein 33 isoform X15

  2. XM_017022630.1XP_016878119.1  coiled-coil domain-containing protein 33 isoform X10

  3. XM_011522085.3XP_011520387.1  coiled-coil domain-containing protein 33 isoform X1

    Conserved Domains (2) summary
    cd00030
    Location:255350
    C2; C2 domain
    pfam16046
    Location:592727
    FAM76; FAM76 protein
  4. XM_017022623.1XP_016878112.1  coiled-coil domain-containing protein 33 isoform X2

  5. XM_017022626.2XP_016878115.1  coiled-coil domain-containing protein 33 isoform X5

  6. XM_017022631.1XP_016878120.1  coiled-coil domain-containing protein 33 isoform X11

  7. XM_017022624.1XP_016878113.1  coiled-coil domain-containing protein 33 isoform X3

  8. XM_017022625.1XP_016878114.1  coiled-coil domain-containing protein 33 isoform X4

  9. XM_017022628.1XP_016878117.1  coiled-coil domain-containing protein 33 isoform X7

  10. XM_017022627.1XP_016878116.1  coiled-coil domain-containing protein 33 isoform X6

  11. XM_011522088.1XP_011520390.1  coiled-coil domain-containing protein 33 isoform X9

    See identical proteins and their annotated locations for XP_011520390.1

    Conserved Domains (1) summary
    cd00030
    Location:37132
    C2; C2 domain
  12. XM_011522087.2XP_011520389.1  coiled-coil domain-containing protein 33 isoform X9

    See identical proteins and their annotated locations for XP_011520389.1

    Conserved Domains (1) summary
    cd00030
    Location:37132
    C2; C2 domain
  13. XM_011522086.1XP_011520388.1  coiled-coil domain-containing protein 33 isoform X8

    Related
    ENSP00000453542.1, ENST00000558659.5
    Conserved Domains (2) summary
    cd00030
    Location:43138
    C2; C2 domain
    pfam16046
    Location:380515
    FAM76; FAM76 protein
  14. XM_005254692.2XP_005254749.1  coiled-coil domain-containing protein 33 isoform X9

    See identical proteins and their annotated locations for XP_005254749.1

    Conserved Domains (1) summary
    cd00030
    Location:37132
    C2; C2 domain
  15. XM_011522089.3XP_011520391.1  coiled-coil domain-containing protein 33 isoform X12

    Conserved Domains (1) summary
    TIGR02169
    Location:135278
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  16. XM_011522090.2XP_011520392.2  coiled-coil domain-containing protein 33 isoform X13

  17. XM_017022632.2XP_016878121.1  coiled-coil domain-containing protein 33 isoform X14

RNA

  1. XR_001751400.1 RNA Sequence

  2. XR_001751401.1 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160016.1 Reference GRCh38.p13 PATCHES

    Range
    65595..165410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_108023.1: Suppressed sequence

    Description
    NR_108023.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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