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MAP3K19 mitogen-activated protein kinase kinase kinase 19 [ Homo sapiens (human) ]

Gene ID: 80122, updated on 26-Oct-2022

Summary

Official Symbol
MAP3K19provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 19provided by HGNC
Primary source
HGNC:HGNC:26249
See related
Ensembl:ENSG00000176601 AllianceGenome:HGNC:26249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCK; YSK4
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 2.7), lung (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See MAP3K19 in Genome Data Viewer
Location:
2q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134964491..135047447, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (135404909..135487908, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135722061..135805017, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene CCNT2 antisense RNA 1 Neighboring gene cyclin T2 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene HNF4 motif-containing MPRA enhancer 203

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23074

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 19
Names
SPS1/STE20-related protein kinase YSK4
YSK4 Sps1/Ste20-related kinase homolog
regulated in COPD kinase
regulated in COPD, protein kinase
yeast Sps1/Ste20-related kinase 4
NP_001018054.1
NP_001018056.1
NP_001018057.1
NP_001269812.1
NP_001308106.1
NP_001387367.1
NP_079328.3
XP_011510193.1
XP_011510198.1
XP_011510199.1
XP_016860493.1
XP_016860494.1
XP_016860495.1
XP_016860496.1
XP_047301873.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018044.3NP_001018054.1  mitogen-activated protein kinase kinase kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001018054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574902, BU676900
    Consensus CDS
    CCDS63020.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000351140.4, ENST00000358371.9
    Conserved Domains (2) summary
    smart00220
    Location:9481211
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9461211
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  2. NM_001018046.3NP_001018056.1  mitogen-activated protein kinase kinase kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_001018056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574904, BU676900
    Consensus CDS
    CCDS33293.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000365004.3, ENST00000375844.7
    Conserved Domains (2) summary
    smart00220
    Location:243506
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:241506
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  3. NM_001018047.3NP_001018057.1  mitogen-activated protein kinase kinase kinase 19 isoform 4

    See identical proteins and their annotated locations for NP_001018057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, and uses two alternate splice sites that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574905, BU676900
    Consensus CDS
    CCDS63022.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376650.3, ENST00000392918.7
    Conserved Domains (2) summary
    smart00220
    Location:227458
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:246458
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001282883.2NP_001269812.1  mitogen-activated protein kinase kinase kinase 19 isoform 5

    See identical proteins and their annotated locations for NP_001269812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AC020602, BC144555, BU676900
    Consensus CDS
    CCDS63021.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376649.3, ENST00000392917.8
    Conserved Domains (2) summary
    smart00220
    Location:206456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:206456
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  5. NM_001321177.2NP_001308106.1  mitogen-activated protein kinase kinase kinase 19 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016725, AK122935, BC034417, BC137277
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENST00000638025.2
    Conserved Domains (1) summary
    cl21453
    Location:10761092
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001400438.1NP_001387367.1  mitogen-activated protein kinase kinase kinase 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016725, AC020602
    Consensus CDS
    CCDS2176.2
    UniProtKB/Swiss-Prot
    Q9H5T2
  7. NM_025052.5NP_079328.3  mitogen-activated protein kinase kinase kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_079328.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016725, AC020602
    Consensus CDS
    CCDS2176.2
    UniProtKB/Swiss-Prot
    Q56UN5, Q9H5T2
    UniProtKB/TrEMBL
    A8MWG7
    Related
    ENSP00000376647.2, ENST00000392915.7
    Conserved Domains (2) summary
    smart00220
    Location:10611324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10591324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    134964491..135047447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005005.3XP_016860494.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:10331296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10311296
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  2. XM_017005004.3XP_016860493.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:10331296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10311296
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  3. XM_017005006.3XP_016860495.1  mitogen-activated protein kinase kinase kinase 19 isoform X4

  4. XM_011511891.3XP_011510193.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:10781341
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:10761341
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  5. XM_011511896.4XP_011510198.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    See identical proteins and their annotated locations for XP_011510198.1

    Conserved Domains (2) summary
    smart00220
    Location:9661229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9641229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  6. XM_011511897.4XP_011510199.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    See identical proteins and their annotated locations for XP_011510199.1

    Conserved Domains (2) summary
    smart00220
    Location:9661229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:9641229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
  7. XM_017005007.2XP_016860496.1  mitogen-activated protein kinase kinase kinase 19 isoform X6

  8. XM_047445917.1XP_047301873.1  mitogen-activated protein kinase kinase kinase 19 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    135404909..135487908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018043.1: Suppressed sequence

    Description
    NM_001018043.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NM_001018045.1: Suppressed sequence

    Description
    NM_001018045.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.