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ARL14 ADP ribosylation factor like GTPase 14 [ Homo sapiens (human) ]

Gene ID: 80117, updated on 11-Jun-2021

Summary

Official Symbol
ARL14provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 14provided by HGNC
Primary source
HGNC:HGNC:22974
See related
Ensembl:ENSG00000179674 MIM:614439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARF7
Orthologs
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Genomic context

See ARL14 in Genome Data Viewer
Location:
3q25.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (160677160..160678448)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160394948..160396236)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 12 Neighboring gene ribosomal protein L6 pseudogene 8 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1L Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
GeneReviews: Not available
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ22595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 14
Names
ADP-ribosylation factor 7
ADP-ribosylation factor-like 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025047.3NP_079323.1  ADP-ribosylation factor-like protein 14

    See identical proteins and their annotated locations for NP_079323.1

    Status: VALIDATED

    Source sequence(s)
    BC034354, BM760777
    Consensus CDS
    CCDS3192.1
    UniProtKB/Swiss-Prot
    Q8N4G2
    Related
    ENSP00000323847.2, ENST00000320767.4
    Conserved Domains (2) summary
    cd04156
    Location:15174
    ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
    smart00178
    Location:1175
    SAR; Sar1p-like members of the Ras-family of small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    160677160..160678448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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