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ZNF606 zinc finger protein 606 [ Homo sapiens (human) ]

Gene ID: 80095, updated on 25-Jan-2022

Summary

Official Symbol
ZNF606provided by HGNC
Official Full Name
zinc finger protein 606provided by HGNC
Primary source
HGNC:HGNC:25879
See related
Ensembl:ENSG00000166704 MIM:613905; AllianceGenome:HGNC:25879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF328
Summary
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF606 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57977053..58003346, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58488421..58514714, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 19 Neighboring gene chromosome 19 open reading frame 18 Neighboring gene uncharacterized LOC100128398 Neighboring gene vomeronasal 2 receptor 19, pseudogene Neighboring gene zinc finger and SCAN domain containing 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14260, KIAA1852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 606
Names
zinc finger protein 328

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053170.1 RefSeqGene

    Range
    5001..31294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348022.3NP_001334951.1  zinc finger protein 606 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB058755, AI766866, AK024322, DA800130
    Consensus CDS
    CCDS12968.1
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    A0A024R4S7, Q9H7U2
    Related
    ENSP00000446972.2, ENST00000551380.7
    Conserved Domains (3) summary
    smart00349
    Location:62122
    KRAB; krueppel associated box
    COG5048
    Location:383774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001348023.3NP_001334952.1  zinc finger protein 606 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AB058755, AI766866, AK024322, AK294037, DA800130
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    B4DFC8, Q9H7U2
    Conserved Domains (3) summary
    COG5048
    Location:293684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. NM_001348024.3NP_001334953.1  zinc finger protein 606 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AB058755, AI766866, AK024322, AK294037
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    B4DFC8, Q9H7U2
    Conserved Domains (3) summary
    COG5048
    Location:293684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. NM_001348025.3NP_001334954.1  zinc finger protein 606 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB058755, AI766866, AK024322, DA577538, DA800130
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    Q9H7U2
    Conserved Domains (2) summary
    COG5048
    Location:225616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_025027.4NP_079303.2  zinc finger protein 606 isoform 1

    See identical proteins and their annotated locations for NP_079303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB058755, AI766866, AK024322
    Consensus CDS
    CCDS12968.1
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    A0A024R4S7, Q9H7U2
    Related
    ENSP00000343617.4, ENST00000341164.9
    Conserved Domains (3) summary
    smart00349
    Location:62122
    KRAB; krueppel associated box
    COG5048
    Location:383774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458478
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57977053..58003346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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