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CCDC15 coiled-coil domain containing 15 [ Homo sapiens (human) ]

Gene ID: 80071, updated on 5-Aug-2026
Official Symbol
CCDC15provided by HGNC
Official Full Name
coiled-coil domain containing 15provided by HGNC
Primary source
HGNC:HGNC:25798
See related
Ensembl:ENSG00000149548 MIM:621146; AllianceGenome:HGNC:25798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in cilium assembly and positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis (RPKM 5.0), skin (RPKM 0.7) and 17 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CCDC15 in Genome Data Viewer
Location:
11q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124954202..125041489)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124982721..125070161)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124824098..124911385)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984406 Neighboring gene hepatic and glial cell adhesion molecule Neighboring gene hepatocellular carcinoma, down-regulated 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:124823758-124824301 Neighboring gene CCDC15 divergent transcript Neighboring gene MPRA-validated peak1499 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124853252-124854004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5693 Neighboring gene solute carrier family 37 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124951446-124951995 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124952423-124953622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5694 Neighboring gene transmembrane protein 218

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity. Arslanhan MD, et al. J Cell Biol, 2023 Dec 4. PMID 37934472, Free PMC Article
  2. Proximity interactions among centrosome components identify regulators of centriole duplication. Firat-Karalar EN, et al. Curr Biol, 2014 Mar 17. PMID 24613305, Free PMC Article
  3. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. Roewenstrunk J, et al. Sci Rep, 2019 Apr 12. PMID 30979931, Free PMC Article
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. Deng X, et al. PLoS One, 2013. PMID 24324551, Free PMC Article
  5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity.
    Title: CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13215

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of centriole elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
coiled-coil domain-containing protein 15

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052613.1 RefSeqGene

    Range
    5082..92369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025004.3 → NP_079280.2  coiled-coil domain-containing protein 15

    See identical proteins and their annotated locations for NP_079280.2

    Status: VALIDATED

    Source sequence(s)
    AK023277, AP003501, AW339835, BC018540, BU569785, DB516555
    Consensus CDS
    CCDS44756.1
    UniProtKB/Swiss-Prot
    Q0P6D6, Q9H8U7
    UniProtKB/TrEMBL
    E9PKB1
    Related
    ENSP00000341684.5, ENST00000344762.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    124954202..125041489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018346.2 → XP_016873835.1  coiled-coil domain-containing protein 15 isoform X1

    UniProtKB/TrEMBL
    A0ACI8T357

  2. XM_017018348.2 → XP_016873837.1  coiled-coil domain-containing protein 15 isoform X3

    UniProtKB/TrEMBL
    A0ACI8T357

  3. XM_047427627.1 → XP_047283583.1  coiled-coil domain-containing protein 15 isoform X5

    UniProtKB/TrEMBL
    A0ACI8T374

  4. XM_017018350.2 → XP_016873839.1  coiled-coil domain-containing protein 15 isoform X6

    UniProtKB/TrEMBL
    A0ACI8T374

  5. XM_017018351.2 → XP_016873840.1  coiled-coil domain-containing protein 15 isoform X8

    UniProtKB/TrEMBL
    A0ACI8QXM0

  6. XM_017018353.2 → XP_016873842.1  coiled-coil domain-containing protein 15 isoform X10

    Related
    ENSP00000777018.1, ENST00001107213.1

  7. XM_017018347.2 → XP_016873836.1  coiled-coil domain-containing protein 15 isoform X2

    UniProtKB/TrEMBL
    A0ACI8T357

  8. XM_047427628.1 → XP_047283584.1  coiled-coil domain-containing protein 15 isoform X7

  9. XM_047427630.1 → XP_047283586.1  coiled-coil domain-containing protein 15 isoform X11

  10. XM_017018352.2 → XP_016873841.1  coiled-coil domain-containing protein 15 isoform X9

  11. XM_017018349.2 → XP_016873838.1  coiled-coil domain-containing protein 15 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    124982721..125070161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370014.1 → XP_054225989.1  coiled-coil domain-containing protein 15 isoform X1

    UniProtKB/TrEMBL
    A0ACI8T357

  2. XM_054370016.1 → XP_054225991.1  coiled-coil domain-containing protein 15 isoform X3

    UniProtKB/TrEMBL
    A0ACI8T357

  3. XM_054370018.1 → XP_054225993.1  coiled-coil domain-containing protein 15 isoform X5

    UniProtKB/TrEMBL
    A0ACI8T374

  4. XM_054370019.1 → XP_054225994.1  coiled-coil domain-containing protein 15 isoform X6

    UniProtKB/TrEMBL
    A0ACI8T374

  5. XM_054370021.1 → XP_054225996.1  coiled-coil domain-containing protein 15 isoform X8

    UniProtKB/TrEMBL
    A0ACI8QXM0

  6. XM_054370023.1 → XP_054225998.1  coiled-coil domain-containing protein 15 isoform X10

  7. XM_054370015.1 → XP_054225990.1  coiled-coil domain-containing protein 15 isoform X2

    UniProtKB/TrEMBL
    A0ACI8T357

  8. XM_054370020.1 → XP_054225995.1  coiled-coil domain-containing protein 15 isoform X7

  9. XM_054370024.1 → XP_054225999.1  coiled-coil domain-containing protein 15 isoform X11

  10. XM_054370022.1 → XP_054225997.1  coiled-coil domain-containing protein 15 isoform X9

  11. XM_054370017.1 → XP_054225992.1  coiled-coil domain-containing protein 15 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P6D6.2 GenPept UniProtKB/Swiss-Prot:Q0P6D6

Gene LinkOut

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