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ATF7IP2 activating transcription factor 7 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80063, updated on 21-Dec-2022

Summary

Official Symbol
ATF7IP2provided by HGNC
Official Full Name
activating transcription factor 7 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:20397
See related
Ensembl:ENSG00000166669 MIM:613645; AllianceGenome:HGNC:20397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCAF2
Summary
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.9), lymph node (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See ATF7IP2 in Genome Data Viewer
Location:
16p13.2-p13.13
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10386061..10483638)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10421735..10519259)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10479918..10577495)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371078 Neighboring gene VISTA enhancer hs1242 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1137 Neighboring gene uncharacterized LOC107984877 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1145 Neighboring gene RNA, U6 small nuclear 633, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activating transcription factor 7-interacting protein 2
Names
ATF7-interacting protein 2
MBD1-containing chromatin associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256160.3NP_001243089.1  activating transcription factor 7-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001243089.1

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK093414, AL832987, BC144468
    Consensus CDS
    CCDS58422.1
    UniProtKB/Swiss-Prot
    Q5U623
    Related
    ENSP00000379807.1, ENST00000396559.5
    Conserved Domains (1) summary
    pfam16788
    Location:291496
    ATF7IP_BD; ATF-interacting protein binding domain
  2. NM_001352120.2NP_001339049.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    Q9H9L6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  3. NM_001393719.1NP_001380648.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    Q9H9L6
    Related
    ENSP00000457731.2, ENST00000562102.6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  4. NM_024997.5NP_079273.2  activating transcription factor 7-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079273.2

    Status: VALIDATED

    Source sequence(s)
    AC131649, AL832987, BC033891, BC137079
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    Q5U623, Q9H9L6
    Related
    ENSP00000379808.2, ENST00000396560.6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain

RNA

  1. NR_045815.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Related
    ENST00000568027.5
  2. NR_045816.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK299040, AL832987, BC144468
  3. NR_147927.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    10386061..10483638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434683.1XP_047290639.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H9L6
  2. XM_047434684.1XP_047290640.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H9L6
  3. XM_017023707.3XP_016879196.1  activating transcription factor 7-interacting protein 2 isoform X3

    Related
    ENSP00000440791.1, ENST00000535850.5
  4. XM_006720954.5XP_006721017.1  activating transcription factor 7-interacting protein 2 isoform X5

    Conserved Domains (1) summary
    pfam16788
    Location:291366
    ATF7IP_BD; ATF-interacting protein binding domain
  5. XM_006720953.4XP_006721016.1  activating transcription factor 7-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006721016.1

    UniProtKB/Swiss-Prot
    Q5U623, Q9H9L6
    Related
    ENSP00000348799.2, ENST00000356427.2
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  6. XM_047434685.1XP_047290641.1  activating transcription factor 7-interacting protein 2 isoform X2

    Related
    ENSP00000322811.5, ENST00000324570.9
  7. XM_017023708.2XP_016879197.1  activating transcription factor 7-interacting protein 2 isoform X4

  8. XM_011522666.3XP_011520968.1  activating transcription factor 7-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    pfam16788
    Location:7108
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:186285
    fn3_4; Fibronectin-III type domain

RNA

  1. XR_007064920.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    10421735..10519259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)