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ATF7IP2 activating transcription factor 7 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80063, updated on 27-Nov-2024

Summary

Official Symbol
ATF7IP2provided by HGNC
Official Full Name
activating transcription factor 7 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:20397
See related
Ensembl:ENSG00000166669 MIM:613645; AllianceGenome:HGNC:20397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCAF2
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 6.9), lymph node (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See ATF7IP2 in Genome Data Viewer
Location:
16p13.2-p13.13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10386061..10483638)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10421735..10519259)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10479918..10577495)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371078 Neighboring gene VISTA enhancer hs1242 Neighboring gene RNA, 7SL, cytoplasmic 493, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10378 Neighboring gene MPRA-validated peak2497 silencer Neighboring gene CRISPRi-validated cis-regulatory element chr16.1137 Neighboring gene Sharpr-MPRA regulatory region 5183 Neighboring gene MPRA-validated peak2499 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7192 Neighboring gene uncharacterized LOC107984877 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1145 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:10597803-10598610 Neighboring gene RNA, U6 small nuclear 633, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10380 Neighboring gene long intergenic non-protein coding RNA 1290

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
activating transcription factor 7-interacting protein 2
Names
ATF7-interacting protein 2
MBD1-containing chromatin associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256160.3NP_001243089.1  activating transcription factor 7-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001243089.1

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK093414, AL832987, BC144468
    Consensus CDS
    CCDS58422.1
    UniProtKB/Swiss-Prot
    Q5U623
    Related
    ENSP00000379807.1, ENST00000396559.5
    Conserved Domains (1) summary
    pfam16788
    Location:291496
    ATF7IP_BD; ATF-interacting protein binding domain
  2. NM_001352120.2NP_001339049.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  3. NM_001393719.1NP_001380648.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000457731.2, ENST00000562102.6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  4. NM_024997.5NP_079273.2  activating transcription factor 7-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079273.2

    Status: VALIDATED

    Source sequence(s)
    AC131649, AL832987, BC033891, BC137079
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000379808.2, ENST00000396560.6
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain

RNA

  1. NR_045815.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Related
    ENST00000568027.5
  2. NR_045816.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK299040, AL832987, BC144468
  3. NR_147927.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    10386061..10483638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434683.1XP_047290639.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
  2. XM_047434684.1XP_047290640.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
  3. XM_017023707.3XP_016879196.1  activating transcription factor 7-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    H3BPC9
    Related
    ENSP00000440791.1, ENST00000535850.5
  4. XM_006720954.5XP_006721017.1  activating transcription factor 7-interacting protein 2 isoform X5

    UniProtKB/TrEMBL
    H3BPC9
    Conserved Domains (1) summary
    pfam16788
    Location:291366
    ATF7IP_BD; ATF-interacting protein binding domain
  5. XM_006720953.4XP_006721016.1  activating transcription factor 7-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006721016.1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000348799.2, ENST00000356427.2
    Conserved Domains (2) summary
    pfam16788
    Location:292496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574673
    fn3_4; Fibronectin-III type domain
  6. XM_047434685.1XP_047290641.1  activating transcription factor 7-interacting protein 2 isoform X2

    Related
    ENSP00000322811.5, ENST00000324570.9
  7. XM_017023708.2XP_016879197.1  activating transcription factor 7-interacting protein 2 isoform X4

  8. XM_011522666.3XP_011520968.1  activating transcription factor 7-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    pfam16788
    Location:7108
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:186285
    fn3_4; Fibronectin-III type domain

RNA

  1. XR_007064920.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    10421735..10519259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313990.1XP_054169965.1  activating transcription factor 7-interacting protein 2 isoform X1

  2. XM_054313991.1XP_054169966.1  activating transcription factor 7-interacting protein 2 isoform X1

  3. XM_054313994.1XP_054169969.1  activating transcription factor 7-interacting protein 2 isoform X3

  4. XM_054313996.1XP_054169971.1  activating transcription factor 7-interacting protein 2 isoform X5

  5. XM_054313992.1XP_054169967.1  activating transcription factor 7-interacting protein 2 isoform X1

  6. XM_054313993.1XP_054169968.1  activating transcription factor 7-interacting protein 2 isoform X2

  7. XM_054313995.1XP_054169970.1  activating transcription factor 7-interacting protein 2 isoform X4

  8. XM_054313997.1XP_054169972.1  activating transcription factor 7-interacting protein 2 isoform X6

RNA

  1. XR_008484739.1 RNA Sequence