U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR157 G protein-coupled receptor 157 [ Homo sapiens (human) ]

Gene ID: 80045, updated on 22-Sep-2022

Summary

Official Symbol
GPR157provided by HGNC
Official Full Name
G protein-coupled receptor 157provided by HGNC
Primary source
HGNC:HGNC:23687
See related
Ensembl:ENSG00000180758 AllianceGenome:HGNC:23687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway and radial glial cell differentiation. Predicted to be located in ciliary membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 10.7), skin (RPKM 5.0) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR157 in Genome Data Viewer
Location:
1p36.22
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9100305..9129102, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (8634357..8663346, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9160364..9189161, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 7 Neighboring gene solute carrier family 2 member 5 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene Sharpr-MPRA regulatory region 7425 Neighboring gene MIR34A host gene Neighboring gene microRNA 34a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 157
Names
probable G-protein coupled receptor 157

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024980.5NP_079256.4  G-protein coupled receptor 157

    See identical proteins and their annotated locations for NP_079256.4

    Status: VALIDATED

    Source sequence(s)
    AL158048, AY768808
    Consensus CDS
    CCDS100.2
    UniProtKB/Swiss-Prot
    Q5UAW9, Q9HA73
    Related
    ENSP00000366628.4, ENST00000377411.5
    Conserved Domains (1) summary
    cl21561
    Location:92169
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9100305..9129102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263497.6XP_005263554.1  G-protein coupled receptor 157 isoform X2

    Conserved Domains (1) summary
    cl21561
    Location:92169
    7tm_4; Olfactory receptor
  2. XM_005263496.6XP_005263553.1  G-protein coupled receptor 157 isoform X1

    Conserved Domains (1) summary
    cl21561
    Location:92169
    7tm_4; Olfactory receptor

RNA

  1. XR_007063977.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    8634357..8663346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)