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CSRNP3 cysteine and serine rich nuclear protein 3 [ Homo sapiens (human) ]

Gene ID: 80034, updated on 24-Nov-2020

Summary

Official Symbol
CSRNP3provided by HGNC
Official Full Name
cysteine and serine rich nuclear protein 3provided by HGNC
Primary source
HGNC:HGNC:30729
See related
Ensembl:ENSG00000178662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAIP2; TAIP-2; PPP1R73; FAM130A2
Expression
Broad expression in brain (RPKM 7.4), endometrium (RPKM 2.0) and 15 other tissues See more
Orthologs

Genomic context

See CSRNP3 in Genome Data Viewer
Location:
2q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (165469680..165689407)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (166326157..166545917)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 3 Neighboring gene sodium voltage-gated channel alpha subunit 2 Neighboring gene MAPRE1 pseudogene 3 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene uncharacterized LOC105373730

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11703, FLJ32093, FLJ44141

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
cysteine/serine-rich nuclear protein 3
Names
TGF-beta induced apoptosis protein 2
family with sequence similarity 130, member A2
protein phosphatase 1, regulatory subunit 73

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172173.2NP_001165644.1  cysteine/serine-rich nuclear protein 3

    See identical proteins and their annotated locations for NP_001165644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC019140, AK056655, AK126129
    Consensus CDS
    CCDS2225.1
    UniProtKB/Swiss-Prot
    Q8WYN3
    Related
    ENSP00000498841.1, ENST00000651982.1
    Conserved Domains (1) summary
    pfam16019
    Location:63277
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  2. NM_024969.3NP_079245.2  cysteine/serine-rich nuclear protein 3

    See identical proteins and their annotated locations for NP_079245.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC019140, AK056655, DA500249
    Consensus CDS
    CCDS2225.1
    UniProtKB/Swiss-Prot
    Q8WYN3
    Related
    ENSP00000344042.4, ENST00000342316.8
    Conserved Domains (1) summary
    pfam16019
    Location:63277
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    165469680..165689407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453155.1XP_024308923.1  cysteine/serine-rich nuclear protein 3 isoform X3

    Conserved Domains (1) summary
    pfam16019
    Location:63277
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  2. XM_005246865.4XP_005246922.1  cysteine/serine-rich nuclear protein 3 isoform X2

    UniProtKB/TrEMBL
    J3KQ49
    Related
    ENSP00000387195.1, ENST00000409420.1
    Conserved Domains (1) summary
    pfam16019
    Location:95309
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  3. XM_024453154.1XP_024308922.1  cysteine/serine-rich nuclear protein 3 isoform X1

    Conserved Domains (1) summary
    pfam16019
    Location:110324
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
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