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ZNF556 zinc finger protein 556 [ Homo sapiens (human) ]

Gene ID: 80032, updated on 9-Jun-2025
Official Symbol
ZNF556provided by HGNC
Official Full Name
zinc finger protein 556provided by HGNC
Primary source
HGNC:HGNC:25669
See related
Ensembl:ENSG00000172000 AllianceGenome:HGNC:25669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in ovary (RPKM 2.7), testis (RPKM 0.5) and 4 other tissues See more
Orthologs
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See ZNF556 in Genome Data Viewer
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2867335..2883445)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2842602..2858723)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2867333..2883443)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2820277-2820970 Neighboring gene zinc finger protein 554 Neighboring gene MPRA-validated peak3238 silencer Neighboring gene MPRA-validated peak3239 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9815 Neighboring gene zinc finger protein 555 Neighboring gene ribosomal protein L35a pseudogene 38 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2887583-2887760 Neighboring gene zinc finger protein 57 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2900543-2901114 Neighboring gene zinc finger protein 57

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 556 (ZNF556) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ11637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 556

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300843.2NP_001287772.1  zinc finger protein 556 isoform 2

    See identical proteins and their annotated locations for NP_001287772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino-acid, compared to isoform 1.
    Source sequence(s)
    AK225297, BC009374
    Consensus CDS
    CCDS74254.1
    UniProtKB/TrEMBL
    A0A0C4DGQ3
    Related
    ENSP00000467366.1, ENST00000586426.5
    Conserved Domains (3) summary
    COG5048
    Location:145293
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:148168
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1444
    KRAB; KRAB box
  2. NM_024967.3NP_079243.1  zinc finger protein 556 isoform 1

    See identical proteins and their annotated locations for NP_079243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006130, AK021699, BC009374
    Consensus CDS
    CCDS12097.1
    UniProtKB/Swiss-Prot
    Q96GM3, Q9HAH1
    Related
    ENSP00000302603.2, ENST00000307635.3
    Conserved Domains (5) summary
    COG5048
    Location:146294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:175197
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1443
    KRAB; KRAB box
    pfam13465
    Location:217242
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_145838.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006130

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2867335..2883445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2842602..2858723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)