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FBXL18 F-box and leucine rich repeat protein 18 [ Homo sapiens (human) ]

Gene ID: 80028, updated on 8-Jul-2021

Summary

Official Symbol
FBXL18provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 18provided by HGNC
Primary source
HGNC:HGNC:21874
See related
Ensembl:ENSG00000155034 MIM:609084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbl18
Summary
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in brain (RPKM 2.3), fat (RPKM 1.2) and 24 other tissues See more
Orthologs
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Genomic context

See FBXL18 in Genome Data Viewer
Location:
7p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (5454425..5513809, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5494056..5553440, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 4 Neighboring gene trinucleotide repeat containing 18 Neighboring gene uncharacterized LOC100129484 Neighboring gene microRNA 589 Neighboring gene uncharacterized LOC221946 Neighboring gene actin beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10776, FLJ11467, FLJ26934, FLJ38075, FLJ41541

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321213.2NP_001308142.1  F-box/LRR-repeat protein 18 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006483, AC092171
    UniProtKB/TrEMBL
    B4DH63
    Conserved Domains (3) summary
    sd00034
    Location:345384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3375
    F-box-like; F-box-like
    pfam13900
    Location:763779
    GVQW; Putative domain of unknown function
  2. NM_001363441.2NP_001350370.1  F-box/LRR-repeat protein 18 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006483, AC092171
    Related
    ENSP00000415064.1, ENST00000415009.5
    Conserved Domains (2) summary
    sd00034
    Location:345384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3368
    F-box-like; F-box-like
  3. NM_001363442.2NP_001350371.1  F-box/LRR-repeat protein 18 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006483, AC092171
    Conserved Domains (2) summary
    sd00034
    Location:345384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3368
    F-box-like; F-box-like
  4. NM_001367780.1NP_001354709.1  F-box/LRR-repeat protein 18 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 5.
    Source sequence(s)
    AC006483, AC092171
  5. NM_001367781.1NP_001354710.1  F-box/LRR-repeat protein 18 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform 5.
    Source sequence(s)
    AC006483, AC092171
  6. NM_024963.6NP_079239.3  F-box/LRR-repeat protein 18 isoform 2

    See identical proteins and their annotated locations for NP_079239.3

    Status: REVIEWED

    Source sequence(s)
    AA878073, AC006483, AC092171, AK294949, BC013435, DC307306
    Consensus CDS
    CCDS43546.1
    UniProtKB/TrEMBL
    A0A024R857, B4DH63, Q96D16
    Related
    ENSP00000371805.3, ENST00000382368.8
    Conserved Domains (2) summary
    sd00034
    Location:345384
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3375
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    5454425..5513809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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