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TMEM62 transmembrane protein 62 [ Homo sapiens (human) ]

Gene ID: 80021, updated on 23-Nov-2021

Summary

Official Symbol
TMEM62provided by HGNC
Official Full Name
transmembrane protein 62provided by HGNC
Primary source
HGNC:HGNC:26269
See related
Ensembl:ENSG00000137842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM62 in Genome Data Viewer
Location:
15q15.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43133115..43185147)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43425313..43477342)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 47 Neighboring gene signal peptidase complex subunit 2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 10 Neighboring gene cyclin D1 binding protein 1 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene transglutaminase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23375

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347004.1NP_001333933.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
    Source sequence(s)
    AC068724
  2. NM_001347005.2NP_001333934.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC068724
  3. NM_001347006.2NP_001333935.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
    Source sequence(s)
    AC068724
  4. NM_001347007.2NP_001333936.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
    Source sequence(s)
    AC068724
  5. NM_001347008.1NP_001333937.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 7-11, encodes isoform c.
    Source sequence(s)
    AC068724
  6. NM_001347009.1NP_001333938.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8-11, encodes isoform c.
    Source sequence(s)
    AC068724
  7. NM_001347010.2NP_001333939.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 6-7 and 9-11, encodes isoform c.
    Source sequence(s)
    AC068724
  8. NM_001347011.2NP_001333940.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 6-8 and 10-11, encodes isoform c.
    Source sequence(s)
    AC068724
  9. NM_001347012.2NP_001333941.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 6-9 and 11, encodes isoform c.
    Source sequence(s)
    AC068724
  10. NM_001347013.2NP_001333942.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 6-10, encodes isoform c.
    Source sequence(s)
    AC068724
  11. NM_001347014.1NP_001333943.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform d.
    Source sequence(s)
    AC068724
  12. NM_001347015.2NP_001333944.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform d.
    Source sequence(s)
    AC068724
  13. NM_001347016.2NP_001333945.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform d.
    Source sequence(s)
    AC068724
  14. NM_001347017.2NP_001333946.1  transmembrane protein 62 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
    Source sequence(s)
    AC068724
  15. NM_001347018.2NP_001333947.1  transmembrane protein 62 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
    Source sequence(s)
    AC068724
  16. NM_001347019.1NP_001333948.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 18-20, encodes isoform f.
    Source sequence(s)
    AC068724
  17. NM_001347020.2NP_001333949.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 17 and 19-20, encodes isoform f.
    Source sequence(s)
    AC068724
  18. NM_001347021.2NP_001333950.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 17-18 and 20, encodes isoform f.
    Source sequence(s)
    AC068724
  19. NM_001347023.2NP_001333952.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 17-19, encodes isoform f.
    Source sequence(s)
    AC068724
  20. NM_001347024.1NP_001333953.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 22-26, encodes isoform g.
    Source sequence(s)
    AC068724
  21. NM_001347025.1NP_001333954.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 21 and 23-26, encodes isoform g.
    Source sequence(s)
    AC068724
  22. NM_001347026.2NP_001333955.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 21-22 and 24-26, encodes isoform g.
    Source sequence(s)
    AC068724
  23. NM_001347027.2NP_001333956.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variants 21-23 and 25-26, encodes isoform g.
    Source sequence(s)
    AC068724
  24. NM_001347028.2NP_001333957.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variants 21-24 and 26, encodes isoform g.
    Source sequence(s)
    AC068724
  25. NM_001347029.2NP_001333958.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variants 21-25, encodes isoform g.
    Source sequence(s)
    AC068724
  26. NM_001347030.1NP_001333959.1  transmembrane protein 62 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC068724
  27. NM_001347031.2NP_001333960.1  transmembrane protein 62 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC068724
  28. NM_001347032.2NP_001333961.1  transmembrane protein 62 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC068724
    Related
    ENSP00000458098.1, ENST00000564494.1
  29. NM_001347033.2NP_001333962.1  transmembrane protein 62 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC068724
  30. NM_001347034.2NP_001333963.1  transmembrane protein 62 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC068724
  31. NM_024956.4NP_079232.3  transmembrane protein 62 isoform a

    See identical proteins and their annotated locations for NP_079232.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC009981
    Consensus CDS
    CCDS32210.1
    UniProtKB/Swiss-Prot
    Q0P6H9
    Related
    ENSP00000260403.2, ENST00000260403.7
    Conserved Domains (3) summary
    cd07401
    Location:57345
    MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
    pfam00149
    Location:59259
    Metallophos; Calcineurin-like phosphoesterase
    pfam13754
    Location:351409
    Big_3_4; Bacterial Ig-like domain (group 3)

RNA

  1. NR_144541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724
  2. NR_144542.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724
  3. NR_144543.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724
  4. NR_144544.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43133115..43185147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522071.1XP_011520373.1  transmembrane protein 62 isoform X1

    See identical proteins and their annotated locations for XP_011520373.1

    Conserved Domains (2) summary
    pfam13754
    Location:221279
    Big_3_4; Bacterial Ig-like domain (group 3)
    cl13995
    Location:1215
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  2. XM_024450072.1XP_024305840.1  transmembrane protein 62 isoform X5

    Conserved Domains (1) summary
    cd07401
    Location:57341
    MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
  3. XM_011522074.2XP_011520376.1  transmembrane protein 62 isoform X3

    Conserved Domains (2) summary
    pfam13754
    Location:135193
    Big_3_4; Bacterial Ig-like domain (group 3)
    cl13995
    Location:95129
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  4. XM_024450071.1XP_024305839.1  transmembrane protein 62 isoform X4

    Conserved Domains (1) summary
    cl13995
    Location:92126
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  5. XM_011522073.1XP_011520375.1  transmembrane protein 62 isoform X2

    See identical proteins and their annotated locations for XP_011520375.1

    UniProtKB/Swiss-Prot
    Q0P6H9
    Conserved Domains (1) summary
    cl13995
    Location:1137
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
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