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FOXRED2 FAD dependent oxidoreductase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 80020, updated on 5-Aug-2022

Summary

Official Symbol
FOXRED2provided by HGNC
Official Full Name
FAD dependent oxidoreductase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:26264
See related
Ensembl:ENSG00000100350 MIM:613777; AllianceGenome:HGNC:26264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERFAD
Summary
Enables flavin adenine dinucleotide binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 9.7), ovary (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

See FOXRED2 in Genome Data Viewer
Location:
22q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (36487190..36507040, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (36947364..36967214, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36883237..36903087, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905111 Neighboring gene thioredoxin 2 Neighboring gene uncharacterized LOC105373020 Neighboring gene eukaryotic translation initiation factor 3 subunit D Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23322, FLJ33734

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FAD-dependent oxidoreductase domain-containing protein 2
Names
ER flavoprotein associated with degradation
endoplasmic reticulum flavoprotein associated with degradation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102371.2NP_001095841.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001095841.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1 and encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL022313, BC040351, BG054783
    Consensus CDS
    CCDS13929.1
    UniProtKB/Swiss-Prot
    Q8IWF2, Q9H6M8
    Related
    ENSP00000380401.4, ENST00000397224.9
    Conserved Domains (1) summary
    COG2072
    Location:23245
    CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]
  2. NM_001363041.2NP_001349970.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL022313, BG054783
    Related
    ENSP00000508644.1, ENST00000685612.1
    Conserved Domains (1) summary
    COG2072
    Location:23330
    CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]
  3. NM_001363042.2NP_001349971.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL022313, BG054783
    Related
    ENSP00000508709.1, ENST00000685224.1
    Conserved Domains (1) summary
    COG2072
    Location:23330
    CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]
  4. NM_024955.6NP_079231.4  FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079231.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL022313, AU279706, BC027716, BC040351, BG054783
    Consensus CDS
    CCDS13929.1
    UniProtKB/Swiss-Prot
    Q8IWF2, Q9H6M8
    Related
    ENSP00000216187.6, ENST00000216187.10
    Conserved Domains (1) summary
    COG2072
    Location:23245
    CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    36487190..36507040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441497.1XP_047297453.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X2

    Related
    ENSP00000509129.1, ENST00000691242.1
  2. XM_047441496.1XP_047297452.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6M8
    Related
    ENSP00000510800.1, ENST00000684868.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    36947364..36967214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)