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UBTD1 ubiquitin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 80019, updated on 7-Jun-2020

Summary

Official Symbol
UBTD1provided by HGNC
Official Full Name
ubiquitin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25683
See related
Ensembl:ENSG00000165886 MIM:616388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]
Expression
Broad expression in testis (RPKM 17.5), lung (RPKM 11.7) and 22 other tissues See more
Orthologs

Genomic context

See UBTD1 in Genome Data Viewer
Location:
10q24.1-q24.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97498924..97571206)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99258768..99330960)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 16 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene ankyrin repeat domain 2 Neighboring gene chromosome 10 open reading frame 62 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ubiquitin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024954.5NP_079230.1  ubiquitin domain-containing protein 1

    See identical proteins and their annotated locations for NP_079230.1

    Status: REVIEWED

    Source sequence(s)
    AL359388, BC007331, BM922594, CB306542
    Consensus CDS
    CCDS7465.1
    UniProtKB/Swiss-Prot
    Q9HAC8
    Related
    ENSP00000359698.3, ENST00000370664.4
    Conserved Domains (2) summary
    cd01794
    Location:151220
    DC_UbP_C; dendritic cell derived ubiquitin-like protein
    pfam16455
    Location:25127
    UBD; Ubiquitin-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97498924..97571206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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