Format

Send to:

Choose Destination

NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 80018, updated on 17-Jun-2019

Summary

Official Symbol
NAA25provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 25, NatB auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:25783
See related
Ensembl:ENSG00000111300 MIM:612755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; MDM20; C12orf30
Summary
This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in thyroid (RPKM 4.6), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See NAA25 in Genome Data Viewer
Location:
12q24.13
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (112026689..112108804, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112464493..112546826, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene immediate early response 3 interacting protein 1 pseudogene Neighboring gene endoplasmic reticulum protein 29 Neighboring gene microRNA 3657 Neighboring gene Sharpr-MPRA regulatory region 5940 Neighboring gene TRAF-type zinc finger domain containing 1 Neighboring gene microRNA 6861 Neighboring gene HECT domain E3 ubiquitin protein ligase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
NHGRI GWA Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
NHGRI GWA Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
NHGRI GWA Catalog
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13089, DKFZp667K2112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Names
N-terminal acetyltransferase B complex subunit NAA25
mitochondrial distribution and morphology 20
natB complex subunit MDM20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017071.1 RefSeqGene

    Range
    5001..87143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024953.4NP_079229.2  N-alpha-acetyltransferase 25, NatB auxiliary subunit

    See identical proteins and their annotated locations for NP_079229.2

    Status: REVIEWED

    Source sequence(s)
    AA653507, BC047640, BC113587, BX647450
    Consensus CDS
    CCDS9159.1
    UniProtKB/Swiss-Prot
    Q14CX7
    Related
    ENSP00000261745.4, ENST00000261745.9
    Conserved Domains (3) summary
    sd00008
    Location:506533
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:4773
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:263655
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    112026689..112108804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253938.1XP_005253995.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

    Conserved Domains (2) summary
    sd00008
    Location:370397
    TPR_YbbN; TPR repeat [structural motif]
    pfam09797
    Location:127519
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
  2. XM_006719606.2XP_006719669.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

    Conserved Domains (3) summary
    sd00008
    Location:478505
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:1945
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:235627
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
  3. XM_017019977.1XP_016875466.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X3

RNA

  1. XR_002957380.1 RNA Sequence

    Related
    ENST00000552527.5
  2. XR_944731.3 RNA Sequence

  3. XR_243023.4 RNA Sequence

    Related
    ENST00000549711.5
  4. XR_944730.3 RNA Sequence

    Related
    ENST00000551858.1
Support Center