U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PSME3IP1 proteasome activator subunit 3 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 80011, updated on 5-Mar-2024

Summary

Official Symbol
PSME3IP1provided by HGNC
Official Full Name
proteasome activator subunit 3 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:29856
See related
Ensembl:ENSG00000172775 MIM:617766; AllianceGenome:HGNC:29856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA10; NIP30; PIP30; CDA018; FAM192A; C16orf94
Summary
Involved in negative regulation of proteasomal protein catabolic process and negative regulation of protein binding activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 12.2), testis (RPKM 10.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PSME3IP1 in Genome Data Viewer
Location:
16q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57152466..57186116, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62948740..62982387, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57186378..57220028, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10873 Neighboring gene NLR family CARD domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57060363-57060881 Neighboring gene CFAP69 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57103335-57104060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57104061-57104785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57137039-57137994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57139274-57139873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10882 Neighboring gene copine 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7523 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene Sharpr-MPRA regulatory region 6435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57183845-57184634 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57212532-57213113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7524 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:57220937-57221581 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7526 Neighboring gene uncharacterized LOC124903697 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21799, MGC74898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PSME3-interacting protein
Names
NEFA-interacting nuclear protein NIP30
PA28G interacting protein 30kDa
PA28G-interacting protein
PSME3 interacting protein 30kDa
family with sequence similarity 192 member A
protein FAM192A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354078.1NP_001341007.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  2. NM_001354079.1NP_001341008.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  3. NM_001354080.1NP_001341009.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Related
    ENSP00000457740.1, ENST00000569266.5
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  4. NM_001354081.2NP_001341010.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  5. NM_001354082.1NP_001341011.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  6. NM_001354083.2NP_001341012.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Related
    ENSP00000457850.1, ENST00000567439.5
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  7. NM_001354084.2NP_001341013.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  8. NM_001354085.2NP_001341014.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  9. NM_001354086.2NP_001341015.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  10. NM_001354087.1NP_001341016.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  11. NM_001354088.2NP_001341017.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  12. NM_001354089.2NP_001341018.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  13. NM_001354090.2NP_001341019.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  14. NM_001354091.2NP_001341020.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  15. NM_001354092.2NP_001341021.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  16. NM_001354094.2NP_001341023.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  17. NM_001354095.2NP_001341024.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  18. NM_001354096.2NP_001341025.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  19. NM_001354097.2NP_001341026.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  20. NM_001354098.2NP_001341027.1  PSME3-interacting protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Conserved Domains (1) summary
    pfam10187
    Location:41129
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  21. NM_001354099.2NP_001341028.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  22. NM_001354100.2NP_001341029.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  23. NM_001354101.2NP_001341030.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  24. NM_001354102.2NP_001341031.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  25. NM_001354103.2NP_001341032.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC009090
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  26. NM_024946.4NP_079222.1  PSME3-interacting protein isoform a

    See identical proteins and their annotated locations for NP_079222.1

    Status: VALIDATED

    Source sequence(s)
    AC009090, BC020536, CA308353, DB101263
    Consensus CDS
    CCDS42168.1
    UniProtKB/Swiss-Prot
    Q9GZU8
    Related
    ENSP00000335808.6, ENST00000309137.13
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57152466..57186116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434681.1XP_047290637.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  2. XM_047434680.1XP_047290636.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  3. XM_047434679.1XP_047290635.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  4. XM_047434678.1XP_047290634.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  5. XM_047434676.1XP_047290632.1  PSME3-interacting protein isoform X2

  6. XM_047434669.1XP_047290625.1  PSME3-interacting protein isoform X2

  7. XM_047434677.1XP_047290633.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  8. XM_024450454.2XP_024306222.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  9. XM_047434672.1XP_047290628.1  PSME3-interacting protein isoform X2

  10. XM_047434671.1XP_047290627.1  PSME3-interacting protein isoform X2

  11. XM_047434675.1XP_047290631.1  PSME3-interacting protein isoform X2

  12. XM_047434670.1XP_047290626.1  PSME3-interacting protein isoform X2

  13. XM_047434673.1XP_047290629.1  PSME3-interacting protein isoform X2

  14. XM_017023704.1XP_016879193.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  15. XM_017023681.3XP_016879170.1  PSME3-interacting protein isoform X3

    Conserved Domains (1) summary
    pfam10187
    Location:21109
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
  16. XM_047434668.1XP_047290624.1  PSME3-interacting protein isoform X1

  17. XM_017023703.2XP_016879192.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
    Conserved Domains (1) summary
    pfam10187
    Location:15116
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62948740..62982387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313972.1XP_054169947.1  PSME3-interacting protein isoform X2

  2. XM_054313982.1XP_054169957.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  3. XM_054313973.1XP_054169948.1  PSME3-interacting protein isoform X2

  4. XM_054313971.1XP_054169946.1  PSME3-interacting protein isoform X2

  5. XM_054313975.1XP_054169950.1  PSME3-interacting protein isoform X2

  6. XM_054313986.1XP_054169961.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  7. XM_054313985.1XP_054169960.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  8. XM_054313984.1XP_054169959.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  9. XM_054313980.1XP_054169955.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  10. XM_054313976.1XP_054169951.1  PSME3-interacting protein isoform X2

  11. XM_054313970.1XP_054169945.1  PSME3-interacting protein isoform X2

  12. XM_054313974.1XP_054169949.1  PSME3-interacting protein isoform X2

  13. XM_054313989.1XP_054169964.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  14. XM_054313981.1XP_054169956.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  15. XM_054313978.1XP_054169953.1  PSME3-interacting protein isoform X2

  16. XM_054313987.1XP_054169962.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  17. XM_054313983.1XP_054169958.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8
  18. XM_054313977.1XP_054169952.1  PSME3-interacting protein isoform X2

  19. XM_054313979.1XP_054169954.1  PSME3-interacting protein isoform X3

  20. XM_054313969.1XP_054169944.1  PSME3-interacting protein isoform X1

  21. XM_054313988.1XP_054169963.1  PSME3-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q9GZU8