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C10orf88 chromosome 10 open reading frame 88 [ Homo sapiens (human) ]

Gene ID: 80007, updated on 4-Jan-2025

Summary

Official Symbol
C10orf88provided by HGNC
Official Full Name
chromosome 10 open reading frame 88provided by HGNC
Primary source
HGNC:HGNC:25822
See related
Ensembl:ENSG00000119965 MIM:620661; AllianceGenome:HGNC:25822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAAT
Summary
Enables ATP hydrolysis activity. Predicted to be involved in chromatin looping and chromatin remodeling. Located in mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis (RPKM 4.0), brain (RPKM 1.9) and 24 other tissues See more
Orthologs
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Genomic context

See C10orf88 in Genome Data Viewer
Location:
10q26.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122930901..122954227, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123805885..123829210, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124690417..124713743, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FAM24B-CUZD1 readthrough Neighboring gene family with sequence similarity 24 member B Neighboring gene ReSE screen-validated silencer GRCh37_chr10:124644309-124644439 Neighboring gene C10orf88B (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 13232 Neighboring gene family with sequence similarity 24 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2894 Neighboring gene uncharacterized LOC124902519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4143 Neighboring gene phosphoseryl-tRNA kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13490

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
 
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATPase PAAT
Names
protein associated with ABC transporters
uncharacterized protein C10orf88
NP_079218.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024942.4NP_079218.2  ATPase PAAT

    See identical proteins and their annotated locations for NP_079218.2

    Status: VALIDATED

    Source sequence(s)
    AC073585, BC032645, CB044034
    Consensus CDS
    CCDS7632.1
    UniProtKB/Swiss-Prot
    Q0P6C6, Q8N597, Q9H8K7
    Related
    ENSP00000419126.1, ENST00000481909.2
    Conserved Domains (1) summary
    pfam14958
    Location:59197
    DUF4506; Domain of unknown function (DUF4506)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    122930901..122954227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    123805885..123829210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)