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DOCK5 dedicator of cytokinesis 5 [ Homo sapiens (human) ]

Gene ID: 80005, updated on 4-Oct-2020

Summary

Official Symbol
DOCK5provided by HGNC
Official Full Name
dedicator of cytokinesis 5provided by HGNC
Primary source
HGNC:HGNC:23476
See related
Ensembl:ENSG00000147459 MIM:616904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See DOCK5 in Genome Data Viewer
Location:
8p21.2
Exon count:
53
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (25184689..25415711)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25042287..25273227)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379330 Neighboring gene ependymin related 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10341 Neighboring gene uncharacterized LOC105379331 Neighboring gene microRNA 6876 Neighboring gene Sharpr-MPRA regulatory region 10380 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp451J181, DKFZp779M164, DKFZp781J211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dedicator of cytokinesis protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051765.1 RefSeqGene

    Range
    4918..235940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322810.2NP_001309739.1  dedicator of cytokinesis protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC041005, AC091185, BC015352
    Consensus CDS
    CCDS83265.1
    UniProtKB/TrEMBL
    B9A015
    Related
    ENSP00000387036.1, ENST00000410074.5
  2. NM_024940.8NP_079216.4  dedicator of cytokinesis protein 5 isoform 1

    See identical proteins and their annotated locations for NP_079216.4

    Status: REVIEWED

    Source sequence(s)
    AC041005, AC091185, AK024687, AK026663, AK126249, BC011877, BC015352, BC041761, BE549612, BF195734, BF884637, BX648352, CR627414, CR749353
    Consensus CDS
    CCDS6047.1
    UniProtKB/Swiss-Prot
    Q9H7D0
    UniProtKB/TrEMBL
    Q68DL4
    Related
    ENSP00000276440.7, ENST00000276440.12
    Conserved Domains (4) summary
    cd11708
    Location:12381637
    DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
    cd12051
    Location:1267
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:75434
    DOCK_N; DOCK N-terminus
    cl14603
    Location:442637
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    25184689..25415711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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