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ESRP2 epithelial splicing regulatory protein 2 [ Homo sapiens (human) ]

Gene ID: 80004, updated on 3-Nov-2018

Summary

Official Symbol
ESRP2provided by HGNC
Official Full Name
epithelial splicing regulatory protein 2provided by HGNC
Primary source
HGNC:HGNC:26152
See related
Ensembl:ENSG00000103067 MIM:612960; Vega:OTTHUMG00000137557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBM35B
Summary
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Expression
Ubiquitous expression in skin (RPKM 25.7), esophagus (RPKM 22.3) and 25 other tissues See more
Orthologs

Genomic context

See ESRP2 in Genome Data Viewer
Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (68225968..68236233, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68262450..68270136, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 28 Neighboring gene dihydrouridine synthase 2 Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene microRNA 6773 Neighboring gene phospholipase A2 group XV Neighboring gene solute carrier family 7 member 6 Neighboring gene RNA, U6 small nuclear 1262, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
    FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21918, FLJ22248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
epithelial splicing regulatory protein 2
Names
RNA binding motif protein 35A
RNA-binding motif protein 35B
RNA-binding protein 35B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365264.1NP_001352193.1  epithelial splicing regulatory protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC020978, AK025571
    Conserved Domains (5) summary
    cd12507
    Location:258332
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:474554
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:86214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:342448
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl26464
    Location:565676
    Atrophin-1; Atrophin-1 family
  2. NM_001365265.1NP_001352194.1  epithelial splicing regulatory protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC030146, BG721782, LN680438, T36047
    Conserved Domains (4) summary
    cd12507
    Location:248322
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:464544
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:86214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:332438
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_024939.3NP_079215.2  epithelial splicing regulatory protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079215.2

    Status: VALIDATED

    Source sequence(s)
    BC030146, BG721782, BU943912, T36047
    Consensus CDS
    CCDS10863.1
    UniProtKB/Swiss-Prot
    Q9H6T0
    Related
    ENSP00000418748.2, OTTHUMP00000174864, ENST00000473183.6
    Conserved Domains (4) summary
    cd12507
    Location:248322
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:464544
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:86214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:332438
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    68225968..68236233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256153.5XP_005256210.1  epithelial splicing regulatory protein 2 isoform X1

    Related
    OTTHUMP00000254750
    Conserved Domains (4) summary
    cd12507
    Location:247321
    RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins
    cd12742
    Location:463543
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:86214
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:331437
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_006721273.4XP_006721336.1  epithelial splicing regulatory protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006721336.1

    Conserved Domains (4) summary
    cd12737
    Location:122201
    RRM1_ESRP2; RNA recognition motif 1 in epithelial splicing regulatory protein 2 (ESRP2) and similar proteins
    cd12742
    Location:338418
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:288
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:206312
    RRM_SF; RNA recognition motif (RRM) superfamily
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