gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpt2provided by ZNC
Official Full Name: glutamic pyruvate transaminase (alanine aminotransferase) 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030729-8
See related: Ensembl:ENSDARG00000012199 AllianceGenome:ZFIN:ZDB-GENE-030729-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb580; im:7150662; zgc:165657
Summary: Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-alanine catabolic process. Predicted to act upstream of or within biosynthetic process. Is expressed in several structures, including axial chorda mesoderm; axis; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	7	NC_133182.1 (42237767..42249174)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (41887378..41900076)

Chromosome 7 - NC_133182.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alanine aminotransferase 2

NP_001092227.2

EC 2.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098757.2 → NP_001092227.2 alanine aminotransferase 2

Status: VALIDATED

Source sequence(s)

JBMGRA010000007

UniProtKB/TrEMBL

A0A8M1NDP9, A0AB32TZZ2

Related

ENSDARP00000104098.3, ENSDART00000115090.7

Conserved Domains (2) summary

cd00609
Location:83 → 471

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PTZ00377
Location:2 → 481

PTZ00377; alanine aminotransferase; Provisional