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dio1 iodothyronine deiodinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 799937, updated on 23-Jun-2024

Summary

Official Symbol
dio1provided by ZNC
Official Full Name
iodothyronine deiodinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030328-41
See related
Ensembl:ENSDARG00000042112 AllianceGenome:ZFIN:ZDB-GENE-030328-41
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Deio1; cb685; zgc:92323
Summary
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Orthologs
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Genomic context

See dio1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18039559..18042062, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18003847..18006350, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 11b Neighboring gene single stranded DNA binding protein 3b Neighboring gene zinc finger protein GLIS1 Neighboring gene ribosomal protein S8b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC92323, MGC174383

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables thyroxine 5'-deiodinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thyroxine 5'-deiodinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neural retina development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thyroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
type I iodothyronine deiodinase
Names
deiodinase, iodothyronine, type I
NP_001007284.3
NP_001311333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007283.2NP_001007284.3  type I iodothyronine deiodinase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC155742, CD606655, CK864452, CO929563, CR847832, DN772220, EE331695, EH492365
    UniProtKB/TrEMBL
    A0A8M1N345, A9JRP6
    Related
    ENSDARP00000121555.1, ENSDART00000132596.2
  2. NM_001324404.1NP_001311333.1  type I iodothyronine deiodinase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) is longer, with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AY221259, BC155742, CD606655, CO929563, CR847832, DN772220, EE331695, EH492365
    UniProtKB/TrEMBL
    A0A8M1P8S9, Q802F6

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    18039559..18042062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)