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ELOVL7 ELOVL fatty acid elongase 7 [ Homo sapiens (human) ]

Gene ID: 79993, updated on 12-Oct-2019

Summary

Official Symbol
ELOVL7provided by HGNC
Official Full Name
ELOVL fatty acid elongase 7provided by HGNC
Primary source
HGNC:HGNC:26292
See related
Ensembl:ENSG00000164181 MIM:614451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in prostate (RPKM 8.7), skin (RPKM 7.9) and 18 other tissues See more
Orthologs

Genomic context

See ELOVL7 in Genome Data Viewer
Location:
5q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (60751789..60844292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (60047616..60140101, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1 Neighboring gene keratin 8 pseudogene 31 Neighboring gene ERCC excision repair 8, CSA ubiquitin ligase complex subunit Neighboring gene G protein nucleolar 3 like pseudogene 1 Neighboring gene ERCC8 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23563

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-oxo-arachidoyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-cerotoyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-lignoceronyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid elongase activity EXP
Inferred from Experiment
more info
PubMed 
fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-long-chain 3-ketoacyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, polyunsaturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, saturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongation of very long chain fatty acids protein 7
Names
3-keto acyl-CoA synthase ELOVL7
ELOVL FA elongase 7
ELOVL family member 7, elongation of long chain fatty acids
very long chain 3-ketoacyl-CoA synthase 7
very long chain 3-oxoacyl-CoA synthase 7
NP_001098028.1
NP_001284546.1
NP_001284547.1
NP_079206.2
XP_005248663.1
XP_005248664.1
XP_006714758.1
XP_011541953.1
XP_016865374.1
XP_016865375.1
XP_016865376.1
XP_016865377.1
XP_016865378.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104558.1NP_001098028.1  elongation of very long chain fatty acids protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001098028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB181393, AC104113, AI769834, AL137506, DA247166
    Consensus CDS
    CCDS34164.1
    UniProtKB/Swiss-Prot
    A1L3X0
    Related
    ENSP00000402634.1, ENST00000425382.5
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family
  2. NM_001297617.2NP_001284546.1  elongation of very long chain fatty acids protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001284546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two additional exons in the 5' region, which results in translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and has an alternate N-terminus, compared to isoform 1.
    Source sequence(s)
    AB181393, AC104113, AI769834, BC094792
    Consensus CDS
    CCDS78013.1
    UniProtKB/Swiss-Prot
    A1L3X0
    UniProtKB/TrEMBL
    D6RHD0
    Related
    ENSP00000421043.1, ENST00000505959.5
    Conserved Domains (1) summary
    pfam01151
    Location:17256
    ELO; GNS1/SUR4 family
  3. NM_001297618.2NP_001284547.1  elongation of very long chain fatty acids protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site, which causes translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104113, AI769834, AL137506, BC144257
    UniProtKB/Swiss-Prot
    A1L3X0
    Conserved Domains (1) summary
    pfam01151
    Location:4182
    ELO; GNS1/SUR4 family
  4. NM_024930.3NP_079206.2  elongation of very long chain fatty acids protein 7 isoform 1

    See identical proteins and their annotated locations for NP_079206.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB181393, AC104113, AI769834, AL137506, DA247166
    Consensus CDS
    CCDS34164.1
    UniProtKB/Swiss-Prot
    A1L3X0
    Related
    ENSP00000424123.1, ENST00000508821.6
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    60751789..60844292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714695.4XP_006714758.1  elongation of very long chain fatty acids protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006714758.1

    UniProtKB/Swiss-Prot
    A1L3X0
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family
  2. XM_011543651.3XP_011541953.1  elongation of very long chain fatty acids protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011541953.1

    UniProtKB/Swiss-Prot
    A1L3X0
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family
  3. XM_017009885.2XP_016865374.1  elongation of very long chain fatty acids protein 7 isoform X1

    UniProtKB/Swiss-Prot
    A1L3X0
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family
  4. XM_017009886.2XP_016865375.1  elongation of very long chain fatty acids protein 7 isoform X2

    UniProtKB/TrEMBL
    D6RHD0
    Conserved Domains (1) summary
    pfam01151
    Location:17256
    ELO; GNS1/SUR4 family
  5. XM_005248606.5XP_005248663.1  elongation of very long chain fatty acids protein 7 isoform X1

    See identical proteins and their annotated locations for XP_005248663.1

    UniProtKB/Swiss-Prot
    A1L3X0
    Conserved Domains (1) summary
    pfam01151
    Location:30269
    ELO; GNS1/SUR4 family
  6. XM_005248607.4XP_005248664.1  elongation of very long chain fatty acids protein 7 isoform X2

    See identical proteins and their annotated locations for XP_005248664.1

    UniProtKB/TrEMBL
    D6RHD0
    Conserved Domains (1) summary
    pfam01151
    Location:17256
    ELO; GNS1/SUR4 family
  7. XM_017009887.2XP_016865376.1  elongation of very long chain fatty acids protein 7 isoform X2

    UniProtKB/TrEMBL
    D6RHD0
    Conserved Domains (1) summary
    pfam01151
    Location:17256
    ELO; GNS1/SUR4 family
  8. XM_017009888.1XP_016865377.1  elongation of very long chain fatty acids protein 7 isoform X3

  9. XM_017009889.2XP_016865378.1  elongation of very long chain fatty acids protein 7 isoform X4

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