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WLS Wnt ligand secretion mediator [ Homo sapiens (human) ]

Gene ID: 79971, updated on 15-Jun-2019

Summary

Official Symbol
WLSprovided by HGNC
Official Full Name
Wnt ligand secretion mediatorprovided by HGNC
Primary source
HGNC:HGNC:30238
See related
Ensembl:ENSG00000116729 MIM:611514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVI; MRP; GPR177; mig-14; C1orf139
Expression
Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues See more
Orthologs

Genomic context

See WLS in Genome Data Viewer
Location:
1p31.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (68098459..68233018, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (68564142..68698284, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GNG12, DIRAS3 and WLS antisense RNA 1 Neighboring gene sirtuin 5 pseudogene Neighboring gene ADP ribosylation factor like GTPase 5A pseudogene 3 Neighboring gene DIRAS family GTPase 3 Neighboring gene C-terminal binding protein 2 pseudogene 8 Neighboring gene microRNA 1262 Neighboring gene ribosomal protein S7 pseudogene 4 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
NHGRI GWA Catalog
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

Pathways from BioSystems

  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
    WNT ligand biogenesis and trafficking, organism-specific biosystem19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the c...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23091, MGC14878, MGC131760, DKFZp686I0788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mu-type opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
 
exocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein wntless homolog
Names
G protein-coupled receptor 177
integral membrane protein GPR177
protein evenness interrupted homolog
putative NF-kappa-B-activating protein 373
putative NFkB activating protein 373
wntless Wnt ligand secretion mediator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002292.3NP_001002292.3  protein wntless homolog isoform 2

    See identical proteins and their annotated locations for NP_001002292.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL513284, BX538320, CA438784, DA753300
    Consensus CDS
    CCDS30750.1
    UniProtKB/Swiss-Prot
    Q5T9L3
    Related
    ENSP00000346829.2, ENST00000354777.6
    Conserved Domains (1) summary
    pfam06664
    Location:176494
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  2. NM_001193334.1NP_001180263.1  protein wntless homolog isoform 3

    See identical proteins and their annotated locations for NP_001180263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AL513284, AW137622, BX648748, DA753300, DB478499
    Consensus CDS
    CCDS53331.1
    UniProtKB/Swiss-Prot
    Q5T9L3
    Related
    ENSP00000360015.3, ENST00000370976.7
    Conserved Domains (1) summary
    pfam06664
    Location:87405
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  3. NM_024911.7NP_079187.3  protein wntless homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_079187.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AW137622, DQ323735
    Consensus CDS
    CCDS642.1
    UniProtKB/Swiss-Prot
    Q5T9L3
    Related
    ENSP00000262348.4, ENST00000262348.9
    Conserved Domains (1) summary
    pfam06664
    Location:178496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    68098459..68233018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542192.3XP_011540494.1  protein wntless homolog isoform X2

    Conserved Domains (1) summary
    pfam06664
    Location:133451
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  2. XM_011542191.2XP_011540493.1  protein wntless homolog isoform X1

    See identical proteins and their annotated locations for XP_011540493.1

    Conserved Domains (1) summary
    pfam06664
    Location:178496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  3. XM_017002390.2XP_016857879.1  protein wntless homolog isoform X3

    Conserved Domains (1) summary
    pfam06664
    Location:133451
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
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