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ATAT1 alpha tubulin acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 79969, updated on 19-Jul-2021

Summary

Official Symbol
ATAT1provided by HGNC
Official Full Name
alpha tubulin acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:21186
See related
Ensembl:ENSG00000137343 MIM:615556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAT; MEC17; C6orf134; Nbla00487; alpha-TAT; alpha-TAT1
Summary
This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in brain (RPKM 7.7), testis (RPKM 3.5) and 23 other tissues See more
Orthologs
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Genomic context

See ATAT1 in Genome Data Viewer
Location:
6p21.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30626874..30646821)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30594651..30614598)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene protein phosphatase 1 regulatory subunit 10 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16 Neighboring gene Sharpr-MPRA regulatory region 567 Neighboring gene protein phosphatase 1 regulatory subunit 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13158, DKFZp547J097

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in alpha-tubulin acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within alpha-tubulin acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in alpha-tubulin acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cilium assembly TAS
Traceable Author Statement
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule bundle IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-tubulin N-acetyltransferase 1
Names
acetyltransferase mec-17 homolog
NP_001026892.1
NP_001177653.1
NP_001241881.1
NP_001305691.1
NP_001305692.1
NP_079185.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031722.4NP_001026892.1  alpha-tubulin N-acetyltransferase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AL662800, BC047303
    Consensus CDS
    CCDS54978.1
    UniProtKB/Swiss-Prot
    Q5SQI0
    UniProtKB/TrEMBL
    A0A1U9X797
    Related
    ENSP00000327832.5, ENST00000330083.6
    Conserved Domains (2) summary
    pfam05301
    Location:10178
    Acetyltransf_16; GNAT acetyltransferase, Mec-17
    cl27975
    Location:183312
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  2. NM_001190724.4NP_001177653.1  alpha-tubulin N-acetyltransferase 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, and lacks an internal in-frame exon, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297661, AL662800, BC047303
    UniProtKB/Swiss-Prot
    Q5SQI0
    UniProtKB/TrEMBL
    B7Z4Q7
    Conserved Domains (1) summary
    pfam05301
    Location:10178
    Acetyltransf_16; GNAT acetyltransferase, Mec-17
  3. NM_001254952.4NP_001241881.1  alpha-tubulin N-acetyltransferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001241881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding region, and lacks an internal in-frame exon, compared to variant 1. The encoded isoform (4) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL662800, BX442806
    Consensus CDS
    CCDS59002.1
    UniProtKB/Swiss-Prot
    Q5SQI0
    Related
    ENSP00000324459.5, ENST00000319027.9
    Conserved Domains (1) summary
    pfam05301
    Location:10190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17
  4. NM_001318762.3NP_001305691.1  alpha-tubulin N-acetyltransferase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and coding region, and lacks an internal in-frame exon, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    BC006105, BX418089
    Consensus CDS
    CCDS83073.1
    UniProtKB/Swiss-Prot
    Q5SQI0
    Related
    ENSP00000324222.7, ENST00000318999.11
    Conserved Domains (1) summary
    pfam05301
    Location:79190
    Mec-17; Touch receptor neuron protein Mec-17
  5. NM_001318763.3NP_001305692.1  alpha-tubulin N-acetyltransferase 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and coding region compared to variant 1. The encoded isoform (6) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AB075512, AK023220, AK225107, BC006105, DB090032
    Consensus CDS
    CCDS83072.1
    UniProtKB/Swiss-Prot
    Q5SQI0
    Related
    ENSP00000365666.4, ENST00000376483.8
    Conserved Domains (2) summary
    PRK14951
    Location:191312
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam05301
    Location:10190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17
  6. NM_024909.5NP_079185.2  alpha-tubulin N-acetyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_079185.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs and coding region compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL535697, AL833858, BX418559, DB090032
    Consensus CDS
    CCDS4683.2
    UniProtKB/Swiss-Prot
    Q5SQI0
    Related
    ENSP00000332374.8, ENST00000329992.12
    Conserved Domains (2) summary
    PHA03307
    Location:197327
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam05301
    Location:10190
    Acetyltransf_16; GNAT acetyltransferase, Mec-17

RNA

  1. NR_033823.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs 5' terminal exon, lacks an internal exon, and contains an alternate segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC025755, CX786272, DB090032
    Related
    ENST00000471782.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30626874..30646821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2106598..2126543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1882704..1902650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1937103..1957050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1970922..1990871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1881962..1901909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1927632..1947580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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