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SCD5 stearoyl-CoA desaturase 5 [ Homo sapiens (human) ]

Gene ID: 79966, updated on 18-Aug-2020

Summary

Official Symbol
SCD5provided by HGNC
Official Full Name
stearoyl-CoA desaturase 5provided by HGNC
Primary source
HGNC:HGNC:21088
See related
Ensembl:ENSG00000145284 MIM:608370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCD2; SCD4; ACOD4; FADS4; HSCD5
Summary
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 129.6), adrenal (RPKM 62.7) and 5 other tissues See more
Orthologs

Genomic context

See SCD5 in Genome Data Viewer
Location:
4q21.22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (82629539..82798796, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83550690..83720010, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 11 pseudogene Neighboring gene long intergenic non-protein coding RNA 575 Neighboring gene PQ loop repeat containing 1 pseudogene 2 Neighboring gene microRNA 575 Neighboring gene SEC31 homolog A, COPII coat complex component Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stearoyl-CoA desaturase 5
Names
acyl-CoA-desaturase 4
stearoyl-CoA 9-desaturase
stearoyl-CoA desaturase 2
stearoyl-CoA desaturase 4
NP_001032671.2
NP_079182.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037582.3NP_001032671.2  stearoyl-CoA desaturase 5 isoform a

    See identical proteins and their annotated locations for NP_001032671.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encoded the longer isoform (A).
    Source sequence(s)
    AF389338, BC048971, DB479400, DR763368
    Consensus CDS
    CCDS34024.1
    UniProtKB/Swiss-Prot
    Q86SK9
    UniProtKB/TrEMBL
    Q86UC8
    Related
    ENSP00000316329.4, ENST00000319540.9
    Conserved Domains (2) summary
    cd03505
    Location:71311
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:77279
    FA_desaturase; Fatty acid desaturase
  2. NM_024906.3NP_079182.2  stearoyl-CoA desaturase 5 isoform b

    See identical proteins and their annotated locations for NP_079182.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC073413
    Consensus CDS
    CCDS3595.1
    UniProtKB/Swiss-Prot
    Q86SK9
    Related
    ENSP00000273908.4, ENST00000273908.4
    Conserved Domains (1) summary
    cd03505
    Location:71159
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    82629539..82798796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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