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NOL10 nucleolar protein 10 [ Homo sapiens (human) ]

Gene ID: 79954, updated on 9-Feb-2020

Summary

Official Symbol
NOL10provided by HGNC
Official Full Name
nucleolar protein 10provided by HGNC
Primary source
HGNC:HGNC:25862
See related
Ensembl:ENSG00000115761 MIM:616197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PQBP5
Expression
Ubiquitous expression in testis (RPKM 4.5), adrenal (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See NOL10 in Genome Data Viewer
Location:
2p25.1
Exon count:
24
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (10570754..10689987, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10710892..10830113, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ODC1 divergent transcript Neighboring gene uncharacterized LOC105373426 Neighboring gene RNA, 7SL, cytoplasmic 832, pseudogene Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene RNA, U7 small nuclear 138 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13938, FLJ14075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar protein 10
Names
H_NH0074G24.1
polyglutamine binding protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261392.1NP_001248321.1  nucleolar protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001248321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC007314, AC092687, AK297169, AL529108, CK904284
    Consensus CDS
    CCDS58697.1
    UniProtKB/Swiss-Prot
    Q9BSC4
    Related
    ENSP00000439663.1, ENST00000538384.5
    Conserved Domains (4) summary
    sd00039
    Location:154189
    7WD40; WD40 repeat [structural motif]
    pfam08159
    Location:456482
    NUC153; NUC153 domain
    cl25539
    Location:156313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26511
    Location:381642
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001261394.1NP_001248323.1  nucleolar protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001248323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AC007314, AC092687, AK024137, AL529108, CK904284, DN602355
    Consensus CDS
    CCDS58698.1
    UniProtKB/Swiss-Prot
    Q9BSC4
    Related
    ENSP00000263837.4, ENST00000345985.7
    Conserved Domains (2) summary
    pfam08159
    Location:432458
    NUC153; NUC153 domain
    cl26511
    Location:357618
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_024894.4NP_079170.2  nucleolar protein 10 isoform 1

    See identical proteins and their annotated locations for NP_079170.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC007314, AC092687
    Consensus CDS
    CCDS1673.2
    UniProtKB/Swiss-Prot
    Q9BSC4
    Related
    ENSP00000371101.5, ENST00000381685.10
    Conserved Domains (4) summary
    COG2319
    Location:24312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5595
    7WD40; WD40 repeat [structural motif]
    pfam08159
    Location:482508
    NUC153; NUC153 domain
    cl26511
    Location:407668
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. NR_048552.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007314, AC092687, AK299617, AL529108, BG390065, BM021448, CK904284

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    10570754..10689987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510399.2XP_011508701.1  nucleolar protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011508701.1

    Conserved Domains (4) summary
    COG2319
    Location:31189
    WD40; WD40 repeat [General function prediction only]
    pfam08159
    Location:332358
    NUC153; NUC153 domain
    sd00039
    Location:3065
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:32189
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011510398.3XP_011508700.1  nucleolar protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011508700.1

    Conserved Domains (4) summary
    COG2319
    Location:31189
    WD40; WD40 repeat [General function prediction only]
    pfam08159
    Location:332358
    NUC153; NUC153 domain
    sd00039
    Location:3065
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:32189
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011510400.2XP_011508702.1  nucleolar protein 10 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:24312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5595
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:182339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_024453152.1XP_024308920.1  nucleolar protein 10 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:24302
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5595
    7WD40; WD40 repeat [structural motif]
  5. XM_024453153.1XP_024308921.1  nucleolar protein 10 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:24302
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5595
    7WD40; WD40 repeat [structural motif]
  6. XM_011510402.2XP_011508704.1  nucleolar protein 10 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:24312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:5595
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:182339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_002959342.1 RNA Sequence

  2. XR_001738957.1 RNA Sequence

  3. XR_001738958.1 RNA Sequence

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