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SYNDIG1 synapse differentiation inducing 1 [ Homo sapiens (human) ]

Gene ID: 79953, updated on 15-Jun-2019

Summary

Official Symbol
SYNDIG1provided by HGNC
Official Full Name
synapse differentiation inducing 1provided by HGNC
Primary source
HGNC:HGNC:15885
See related
Ensembl:ENSG00000101463 MIM:614311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPC2; IFITMD5; TMEM90B; C20orf39
Summary
This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]
Expression
Biased expression in brain (RPKM 1.9), heart (RPKM 1.6) and 11 other tissues See more
Orthologs

Genomic context

See SYNDIG1 in Genome Data Viewer
Location:
20p11.21
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (24469199..24666617)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (24449835..24647253)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372577 Neighboring gene translation initiation factor IF-2-like Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 53 Neighboring gene uncharacterized LOC107985402 Neighboring gene uncharacterized LOC105372578

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synapse differentiation-inducing gene protein 1
Names
dispanin subfamily C member 2
interferon induced transmembrane protein domain containing 5
synapse differentiation induced gene 1
transmembrane protein 90B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323606.1NP_001310535.1  synapse differentiation-inducing gene protein 1

    Status: REVIEWED

    Source sequence(s)
    AK024282, AL034426, AL049594, AL157413, DB306704
    Consensus CDS
    CCDS13164.1
    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein
  2. NM_001323607.1NP_001310536.1  synapse differentiation-inducing gene protein 1

    Status: REVIEWED

    Source sequence(s)
    AL034426, AL049594, AL157413, DB306704
    Consensus CDS
    CCDS13164.1
    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein
  3. NM_024893.3NP_079169.1  synapse differentiation-inducing gene protein 1

    See identical proteins and their annotated locations for NP_079169.1

    Status: REVIEWED

    Source sequence(s)
    AK024282, DB306704
    Consensus CDS
    CCDS13164.1
    UniProtKB/Swiss-Prot
    Q9H7V2
    Related
    ENSP00000366058.3, ENST00000376862.4
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein

RNA

  1. NR_147606.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL034426, AL049594, AL157413

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    24469199..24666617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529356.3XP_011527658.1  synapse differentiation-inducing gene protein 1 isoform X3

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  2. XM_011529358.3XP_011527660.1  synapse differentiation-inducing gene protein 1 isoform X4

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  3. XM_011529347.3XP_011527649.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527649.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  4. XM_011529348.3XP_011527650.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527650.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  5. XM_011529349.3XP_011527651.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527651.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  6. XM_017028069.2XP_016883558.1  synapse differentiation-inducing gene protein 1 isoform X5

  7. XM_011529350.1XP_011527652.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527652.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  8. XM_011529352.2XP_011527654.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527654.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  9. XM_017028065.1XP_016883554.1  synapse differentiation-inducing gene protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein
  10. XM_011529351.1XP_011527653.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527653.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  11. XM_017028067.2XP_016883556.1  synapse differentiation-inducing gene protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein
  12. XM_017028066.2XP_016883555.1  synapse differentiation-inducing gene protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein
  13. XM_011529354.2XP_011527656.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527656.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  14. XM_011529353.2XP_011527655.1  synapse differentiation-inducing gene protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527655.1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  15. XM_017028064.1XP_016883553.1  synapse differentiation-inducing gene protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04505
    Location:177206
    CD225; Interferon-induced transmembrane protein
  16. XM_017028068.1XP_016883557.1  synapse differentiation-inducing gene protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H7V2
    Conserved Domains (1) summary
    pfam04505
    Location:177242
    CD225; Interferon-induced transmembrane protein

RNA

  1. XR_937144.3 RNA Sequence

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