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PLPPR3 phospholipid phosphatase related 3 [ Homo sapiens (human) ]

Gene ID: 79948, updated on 1-Jun-2020

Summary

Official Symbol
PLPPR3provided by HGNC
Official Full Name
phospholipid phosphatase related 3provided by HGNC
Primary source
HGNC:HGNC:23497
See related
Ensembl:ENSG00000129951 MIM:610391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPR3; PRG2; LPPR3; PRG-2
Summary
The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in bone marrow (RPKM 2.7), brain (RPKM 2.5) and 2 other tissues See more
Orthologs

Genomic context

See PLPPR3 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (810966..824244, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (812488..821952, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.129 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 4745 Neighboring gene microRNA 3187 Neighboring gene azurocidin 1 Neighboring gene proteinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 3
Names
PAP-2-like protein 2
lipid phosphate phosphatase-related protein type 3
plasticity-related gene 2 protein
NP_001257295.1
NP_079164.1
XP_011526619.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270366.2NP_001257295.1  phospholipid phosphatase-related protein type 3 isoform 2

    See identical proteins and their annotated locations for NP_001257295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
    Source sequence(s)
    AC004799, AL136596, AY436785, BC012339
    Consensus CDS
    CCDS58636.1
    UniProtKB/Swiss-Prot
    Q6T4P5
    Related
    ENSP00000430297.1, ENST00000520876.7
    Conserved Domains (1) summary
    cd03384
    Location:129278
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_024888.2NP_079164.1  phospholipid phosphatase-related protein type 3 isoform 1

    See identical proteins and their annotated locations for NP_079164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AC006273, AL136596, BC012339
    Consensus CDS
    CCDS12043.1
    UniProtKB/Swiss-Prot
    Q6T4P5
    Related
    ENSP00000352962.2, ENST00000359894.6
    Conserved Domains (1) summary
    cd03384
    Location:129306
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    810966..824244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528317.3XP_011526619.1  phospholipid phosphatase-related protein type 3 isoform X1

    See identical proteins and their annotated locations for XP_011526619.1

    UniProtKB/Swiss-Prot
    Q6T4P5
    Conserved Domains (1) summary
    cd03384
    Location:129306
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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