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KAT6A lysine acetyltransferase 6A [ Homo sapiens (human) ]

Gene ID: 7994, updated on 20-Feb-2017
Official Symbol
KAT6Aprovided by HGNC
Official Full Name
lysine acetyltransferase 6Aprovided by HGNC
Primary source
HGNC:HGNC:13013
See related
Ensembl:ENSG00000083168 MIM:601408; Vega:OTTHUMG00000150453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOZ; MRD32; MYST3; MYST-3; ZNF220; RUNXBP2; ZC2HC6A
Summary
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Orthologs
Location:
8p11.21
Exon count:
19
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (41929479..42052026, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41786997..41909506, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ankyrin 1 Neighboring gene uncharacterized LOC105379392 Neighboring gene RNA, 7SL, cytoplasmic 149, pseudogene Neighboring gene uncharacterized LOC105379393 Neighboring gene myosin light chain 9 pseudogene Neighboring gene ribosomal protein L17 pseudogene 30

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of K(lysine) acetyltransferase 6A (KAT6A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Interaction Database

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystem (from WikiPathways)
    Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystemProtein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and not...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC167033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity TAS
Traceable Author Statement
more info
 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA packaging TAS
Traceable Author Statement
more info
PubMed 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
histone acetyltransferase KAT6A
Names
K(lysine) acetyltransferase 6A
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
MYST histone acetyltransferase (monocytic leukemia) 3
histone acetyltransferase MYST3
monocytic leukemia zinc finger protein
runt-related transcription factor binding protein 2
zinc finger protein 220
NP_001292807.1
NP_006757.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042093.1 RefSeqGene

    Range
    5001..127548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001305878.1NP_001292807.1  histone acetyltransferase KAT6A isoform 2

    See identical proteins and their annotated locations for NP_001292807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons in the 3' coding region and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in differences in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC090571, BC142959, BP248857, BP271264
    Consensus CDS
    CCDS83290.1
    UniProtKB/TrEMBL
    A5PLL3
    Related
    ENSP00000430606, OTTHUMP00000225722, ENST00000485568, OTTHUMT00000318161
    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:565743
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505779
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  2. NM_006766.4NP_006757.2  histone acetyltransferase KAT6A isoform 1

    See identical proteins and their annotated locations for NP_006757.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA310750, AC090571, AJ420560, BC142659, BP248857, CB216817, DA442995, U47742
    Consensus CDS
    CCDS6124.1
    UniProtKB/Swiss-Prot
    Q92794
    UniProtKB/TrEMBL
    A5PKX7
    Related
    ENSP00000265713, OTTHUMP00000197392, ENST00000265713, OTTHUMT00000318160
    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:565743
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505779
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    41929479..42052026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013864.1XP_016869353.1  histone acetyltransferase KAT6A isoform X3

    UniProtKB/Swiss-Prot
    Q92794
    Related
    ENSP00000385888, OTTHUMP00000197394, ENST00000406337, OTTHUMT00000318163
    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:565743
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505779
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  2. XM_011544658.2XP_011542960.1  histone acetyltransferase KAT6A isoform X1

    See identical proteins and their annotated locations for XP_011542960.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:609787
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:549823
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  3. XM_011544659.2XP_011542961.1  histone acetyltransferase KAT6A isoform X2

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:602780
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:542816
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  4. XM_017013863.1XP_016869352.1  histone acetyltransferase KAT6A isoform X3

    UniProtKB/Swiss-Prot
    Q92794
    Related
    ENSP00000380136, ENST00000396930
    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:565743
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505779
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  5. XM_011544656.2XP_011542958.1  histone acetyltransferase KAT6A isoform X1

    See identical proteins and their annotated locations for XP_011542958.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:609787
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:549823
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  6. XM_011544657.2XP_011542959.1  histone acetyltransferase KAT6A isoform X1

    See identical proteins and their annotated locations for XP_011542959.1

    Conserved Domains (5) summary
    smart00526
    Location:85162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    pfam01853
    Location:609787
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:549823
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    41835431..41957840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099412.1: Suppressed sequence

    Description
    NM_001099412.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_001099413.1: Suppressed sequence

    Description
    NM_001099413.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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