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CNTNAP3 contactin associated protein family member 3 [ Homo sapiens (human) ]

Gene ID: 79937, updated on 16-Jul-2021

Summary

Official Symbol
CNTNAP3provided by HGNC
Official Full Name
contactin associated protein family member 3provided by HGNC
Primary source
HGNC:HGNC:13834
See related
Ensembl:ENSG00000106714 MIM:610517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CASPR3; CNTNAP3A
Summary
The protein encoded by this gene belongs to the NCP family of cell-recognition molecules. This family represents a distinct subgroup of the neurexins. NCP proteins mediate neuron-glial interactions in vertebrates and glial-glial contact in invertebrates. The protein encoded by this gene may play a role in cell recognition within the nervous system. Alternatively spliced transcript variants encoding different isoforms have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: suggests misassembly
Expression
Broad expression in esophagus (RPKM 5.9), skin (RPKM 4.1) and 22 other tissues See more
Orthologs
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Genomic context

See CNTNAP3 in Genome Data Viewer
Location:
9p12
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (39064710..39288167, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (39064707..39288164, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927042 Neighboring gene vomeronasal 2 receptor 3, pseudogene Neighboring gene RNA binding motif protein 17 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 640, pseudogene Neighboring gene ubiquitin specific peptidase 12 pseudogene Neighboring gene uncharacterized LOC105376045 Neighboring gene SPATA31 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell recognition NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
contactin-associated protein-like 3
Names
cell recognition molecule Caspr3
contactin associated protein like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393379.1NP_001380308.1  contactin-associated protein-like 3 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162501, AL353729
    Related
    ENSP00000366884.2, ENST00000377656.6
    Conserved Domains (5) summary
    cd00057
    Location:54176
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:371519
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:551582
    EGF; EGF-like domain
    pfam02210
    Location:212341
    Laminin_G_2; Laminin G domain
    cl00085
    Location:590634
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_033655.5NP_387504.2  contactin-associated protein-like 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_387504.2

    Status: REVIEWED

    Source sequence(s)
    AL162501, AL353729
    Consensus CDS
    CCDS6616.1
    UniProtKB/Swiss-Prot
    Q9BZ76
    Related
    ENSP00000297668.6, ENST00000297668.10
    Conserved Domains (6) summary
    smart00231
    Location:55177
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:54176
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:794938
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:551582
    EGF; EGF-like domain
    pfam02210
    Location:212341
    Laminin_G_2; Laminin G domain
    cl00085
    Location:590635
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    39064710..39288167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024879.3: Suppressed sequence

    Description
    NM_024879.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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